CAS 81944-09-4|Z-Ligustilide

Introduction：Basic information about CAS 81944-09-4|Z-Ligustilide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Z-Ligustilide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Z-Ligustilide
CAS Number	81944-09-4	Molecular Weight	190.238
Density	1.1±0.1 g/cm3	Boiling Point	377.9±11.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₄O₂	Melting Point	168～169℃
MSDS	/	Flash Point	158.6±16.7 °C

Names

Name	Ligustilide
Synonym	More Synonyms

Z-Ligustilide BiologicalActivity

Description	(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6[1].(Z)-Ligustilide inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2].
Related Catalog	Research Areas >>InfectionResearch Areas >>Metabolic DiseaseSignaling Pathways >>Anti-infection >>Bacterial
References	[1]. Rodrigues AMS, et al. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Sci Rep. 2019 Jun 19;9(1):8729. doi: 10.1038/s41598-019-45222-y [2]. Ma H, et al. Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa. Oncotarget. 2017 Apr 25;8(17):29328-29345.

Description

(Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6[1].(Z)-Ligustilide inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2].

Related Catalog

Research Areas >>InfectionResearch Areas >>Metabolic DiseaseSignaling Pathways >>Anti-infection >>Bacterial

References

[1]. Rodrigues AMS, et al. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Sci Rep. 2019 Jun 19;9(1):8729. doi: 10.1038/s41598-019-45222-y

[2]. Ma H, et al. Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa. Oncotarget. 2017 Apr 25;8(17):29328-29345.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	377.9±11.0 °C at 760 mmHg
Melting Point	168～169℃
Molecular Formula	C₁₂H₁₄O₂
Molecular Weight	190.238
Flash Point	158.6±16.7 °C
Exact Mass	190.099380
PSA	26.30000
LogP	2.63
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.545
Storage condition	2~8°C

Safety Information

Hazard Codes	Xi

Synonyms

Ligustilide A

Ligustilide

cis-ligustilide

Ligustilide, (Z)-

1(3H)-Isobenzofuranone, 3-butylidene-4,5-dihydro-, (3Z)-

Z-LIGUSTILIDE

(3Z)-3-Butylidene-4,5-dihydro-2-benzofuran-1(3H)-one

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