CAS 2208-41-5|6-Hydroxymelatonin
| Common Name | 6-Hydroxymelatonin | ||
|---|---|---|---|
| CAS Number | 2208-41-5 | Molecular Weight | 248.27800 |
| Density | 1.266g/cm3 | Boiling Point | 564.7ºC at 760mmHg |
| Molecular Formula | C13H16N2O3 | Melting Point | 172-175ºC |
| MSDS | ChineseUSA | Flash Point | 295.3ºC |
| Symbol | GHS07, GHS08 | Signal Word | Warning |
Names
| Name | 6-hydroxymelatonin |
|---|---|
| Synonym | More Synonyms |
6-Hydroxymelatonin BiologicalActivity
| Description | 6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2. |
|---|---|
| Related Catalog | Research Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| References | [1]. Härtter S, et al. Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study. Clin Pharmacol Ther. 2001 Jul;70(1):10-6. |
Chemical & Physical Properties
| Density | 1.266g/cm3 |
|---|---|
| Boiling Point | 564.7ºC at 760mmHg |
| Melting Point | 172-175ºC |
| Molecular Formula | C13H16N2O3 |
| Molecular Weight | 248.27800 |
| Flash Point | 295.3ºC |
| Exact Mass | 248.11600 |
| PSA | 74.35000 |
| LogP | 1.95160 |
| Vapour Pressure | 2.35E-13mmHg at 25°C |
| Index of Refraction | 1.627 |
| InChIKey | OMYMRCXOJJZYKE-UHFFFAOYSA-N |
| SMILES | COc1cc2c(CCNC(C)=O)c[nH]c2cc1O |
| Storage condition | Refrigerator |
| Water Solubility | alcohol: soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 8 mg/kg
- SEX/DURATION :
- male 20 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 33,618,1985
Safety Information
| Symbol | GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H351 |
| Precautionary Statements | P281 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 22-40 |
| Safety Phrases | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AC3607000 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles32
More Articles| Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro. Mol. Cell. Endocrinol. 404 , 1-8, (2015) Melatonin and its metabolites including 6-hydroxymelatonin (6(OH)M), N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) and 5-methoxytryptamine (5MT) are endogenously produced in human epidermis. This... | |
| Predominance of 2-hydroxymelatonin over melatonin in plants. J. Pineal Res. 59 , 448-54, (2015) The cloning of the gene encoding melatonin 2-hydroxylase (M2H), which is responsible for the synthesis of 2-hydroxymelatonin, has expanded the study of melatonin metabolism in plants. Kinetic analysis... | |
| Molecular cloning of melatonin 2-hydroxylase responsible for 2-hydroxymelatonin production in rice (Oryza sativa). J. Pineal Res. 58(3) , 343-51, (2015) Although melatonin biosynthetic genes from plants have been cloned, the melatonin catabolism mechanisms remain unclear. To clone the genes responsible for melatonin metabolism, we ectopically expresse... |
Synonyms
| 6-HydroxyMelatonin |
| 6-Hydroxy Melatonin |
| N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide |
