Introduction：Basic information about CAS 66564-14-5|Cinitapride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cinitapride |
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| CAS Number | 66564-14-5 | Molecular Weight | 402.487 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 579.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H30N4O4 | Melting Point | / |
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| MSDS | / | Flash Point | 304.5±30.1 °C |
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Names
| Name | 4-amino-N-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide |
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| Synonym | More Synonyms |
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Cinitapride BiologicalActivity
| Description | Cinitapride is an orally active 5-HT4 agonist and D2 antagonist. Cinitapride shows gastroprotective properties on mucosal injury. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorSignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| In Vivo | Cinitapride (intraperitoneal injection; 0.25-1 mg/kg; once) shows gastroprotective effetcs in gastric ulceration rat model[2]. Animal Model: Male Wistar rats with gastric ulceration[2] Dosage: 0.25-1 mg/kg Administration: Intraperitoneal injection; 0.25-1 mg/kg; once Result: Reduced haemorrhagic lesions compared with the ulcerated control group. Decreased the percentage of ulceration to 28.76% at the highest dose (1 mg/kg). Attenuated the increase myeloperoxidase activity (p<0.05, p<0.01). Increased GSH-px activity in the gastric mucosa. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 579.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H30N4O4 |
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| Molecular Weight | 402.487 |
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| Flash Point | 304.5±30.1 °C |
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| Exact Mass | 402.226715 |
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| PSA | 113.41000 |
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| LogP | 3.87 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.603 |
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| InChIKey | ZDLBNXXKDMLZMF-UHFFFAOYSA-N |
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| SMILES | CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1 |
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Synonyms
| Cinitaprida |
| 4-Amino-N-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide |
| cidine |
| Cinitapridum |
| Blaston |
| cinitapride |
| Cinmove |
| Paxapride |
| 4-Amino-N-[1-(3-cyclohexen-1-ylmethyl)-4-piperidinyl]-2-ethoxy-5-nitrobenzamide |
| Cintapro |
| Benzamide, 4-amino-N-[1-(3-cyclohexen-1-ylmethyl)-4-piperidinyl]-2-ethoxy-5-nitro- |
