CAS 23964-57-0|Articaine HCl
Introduction：Basic information about CAS 23964-57-0|Articaine HCl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Articaine HCl | ||
|---|---|---|---|
| CAS Number | 23964-57-0 | Molecular Weight | 320.835 |
| Density | 1.178 g/cm3 | Boiling Point | 440.6ºC at 760 mmHg |
| Molecular Formula | C13H21ClN2O3S | Melting Point | 177-178° |
| MSDS | ChineseUSA | Flash Point | 220.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Articaine hydrochloride |
|---|---|
| Synonym | More Synonyms |
Articaine HCl BiologicalActivity
| Description | Articaine Hydrochloride is a dental local anesthetic.Target: OthersArticaine Hydrochloride is a dental local anesthetic. Articaine: VAS (Visual Analogue Scale) scores (from 0 to 10 cm) by patients 4 to < 13 years of age are 0.5 for simple procedures and 1.1 for complex procedures, and average investigator scores are 0.4 and 0.6 for simple and complex procedures, respectively. No serious adverse events related to the articaine occurres, the only adverse event considered related to articaine is accidental lip injury in one patient [1]. Articaine results in success rate of 64.5% in electronic pulp testing in healthy adult volunteers injected with 4% articaine. Articaine infiltration produces significantly more episodes of no response to maximum stimulation in first molars than lidocaine. Mandibular buccal infiltration is more effective with 4% articaine with epinephrine compared to 2% lidocaine with epinephrine [2]. Articaine formulation results in successful pulpal anesthesia ranged from 75 to 92 percent and onset of pulpal anesthesia ranged from 4.2 to 4.7 minutes in healthy volunteer. For articaine, 4 percent (two of 56) of the subjects reported swelling and no subjects reported bruising. Ninety-eight percent (59 of 60) of the subjects had lip numbness with the articaine solution [3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| References | [1]. Malamed, S.F., S. Gagnon, and D. Leblanc, A comparison between articaine HCl and lidocaine HCl in pediatric dental patients. Pediatr Dent, 2000. 22(4): p. 307-11. [2]. Kanaa, M.D., et al., Articaine and lidocaine mandibular buccal infiltration anesthesia: a prospective randomized double-blind cross-over study. J Endod, 2006. 32(4): p. 296-8. [3]. Robertson, D., et al., The anesthetic efficacy of articaine in buccal infiltration of mandibular posterior teeth. J Am Dent Assoc, 2007. 138(8): p. 1104-12. |
Chemical & Physical Properties
| Density | 1.178 g/cm3 |
|---|---|
| Boiling Point | 440.6ºC at 760 mmHg |
| Melting Point | 177-178° |
| Molecular Formula | C13H21ClN2O3S |
| Molecular Weight | 320.835 |
| Flash Point | 220.3ºC |
| Exact Mass | 320.096130 |
| PSA | 95.67000 |
| LogP | 3.43560 |
| Vapour Pressure | 5.79E-08mmHg at 25°C |
| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble20mg/mL, clear |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PAWIAT Praktische Anaesthesie, Wiederbelegung und Intensivtherapie. (Stuttgart, Fed. Rep. Ger.) V.9-14, 1974-79. Volume(issue)/page/year: 9,135,1974
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles26
More Articles| Improving the local anesthesia experience for our patients. Dent. Today 33(4) , 120, 122, 124 passim, (2014) | |
| Thermographic monitoring of wound healing and oral health-related quality of life in patients treated with laser (aPDT) after impacted mandibular third molar removal. Int. J. Oral Maxillofac. Surg. 43(12) , 1503-8, (2014) The objective of this study was to assess the impact of low-level laser therapy on wound swelling, wound temperature changes, and oral health-related quality of life (OHRQoL) after surgical removal of... | |
| Comparison of articaine and lidocaine in the pediatric population. J. Mich. Dent. Assoc. 96(1) , 34-7, (2014) The purpose of this paper was to review the use of articaine in the pediatric dental population. Literature on use of articaine in comparison to lidocaine was reviewed. Many dental procedures on prima... |
Synonyms
| Ultracaine |
| Articaine HCI |
| methyl 4-methyl-3-[(N-propylalanyl)amino]thiophene-2-carboxylate hydrochloride |
| 4-méthyl-3-{[2-(propylamino)propanoyl]amino}thiophène-2-carboxylate de méthyle chlorhydrate |
| Articaine HCl |
| Articaine hydrochloride |
| Methyl 4-methyl-3-[(N-propylalanyl)amino]-2-thiophenecarboxylate hydrochloride (1:1) |
| Methyl 4-methyl-3-[(N-propylalanyl)amino]thiophene-2-carboxylate hydrochloride (1:1) |
| methyl 4-methyl-3-(2-(propylamino)propanamido)thiophene-2-carboxylate hydrochloride |
| Methyl-4-methyl-3-{[2-(propylamino)propanoyl]amino}thiophen-2-carboxylathydrochlorid |
| methyl 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylate,hydrochloride |
| Carticaine HCl |
| methyl 4-methyl-3-{[2-(propylamino)propanoyl]amino}thiophene-2-carboxylate hydrochloride |
| 2-Thiophenecarboxylic acid, 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-, methyl ester, hydrochloride (1:1) |
| Septocaine |
| carticaine hydrochloride |
| Septanest |
| 2-thiophenecarboxylic acid, 4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-, methyl ester, monohydrochloride |
| Articaine (hydrochloride) |
