CAS 327-97-9|Chlorogenic acid
| Common Name | Chlorogenic acid | ||
|---|---|---|---|
| CAS Number | 327-97-9 | Molecular Weight | 354.309 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 665.0±55.0 °C at 760 mmHg |
| Molecular Formula | C16H18O9 | Melting Point | 210 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 245.5±25.0 °C |
Names
| Name | chlorogenic acid |
|---|---|
| Synonym | More Synonyms |
Chlorogenic acid BiologicalActivity
| Description | Chlorogenic acid is a major phenolic compound in coffee and tea. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>HIF/HIF Prolyl-HydroxylaseResearch Areas >>Inflammation/ImmunologyNatural Products >>Phenylpropanoids |
| References | [1]. Park JJ, et al. Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway. Cell Oncol (Dordr). 2015 Jan 6. [2]. Park SH, et al. IRAK4 as a Molecular Target in the Amelioration of Innate Immunity-Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid. J Immunol. 2015 Feb 1;194(3):1122-30. [3]. Kang JW, et al. Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats. Biomol Ther (Seoul). 2014 Sep;22(5):420-5. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 665.0±55.0 °C at 760 mmHg |
| Melting Point | 210 °C (dec.)(lit.) |
| Molecular Formula | C16H18O9 |
| Molecular Weight | 354.309 |
| Flash Point | 245.5±25.0 °C |
| Exact Mass | 354.095093 |
| PSA | 164.75000 |
| LogP | -0.36 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.690 |
| Water Solubility | SOLUBLE IN HOT WATER |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 5-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 250 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 111,209,1983
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 250 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 111,209,1983
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R68 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | GU8480000 |
Articles189
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| Pathway as a pharmacological target for herbal medicines: an investigation from reduning injection. PLoS ONE 10(4) , e0123109, (2015) As a rich natural resource for drug discovery, Traditional Chinese Medicine (TCM) plays an important role in complementary and alternative medical systems. TCM shows a daunting complexity of compounds... | |
| Antioxidant properties, phenolic composition and potentiometric sensor array evaluation of commercial and new blueberry (Vaccinium corymbosum) and bog blueberry (Vaccinium uliginosum) genotypes. Food Chem. 188 , 583-90, (2015) Antioxidant properties of juices of newly bred and known blueberry (Vaccinium corymbosum) genotypes and wild bog blueberry (Vaccinium uliginosum) were evaluated by ABTS(+) scavenging capacity (RSC), f... |
Synonyms
| Hlorogenic acid |
| Chlorogenic Acid Hydrate |
| Caffeoyl quinic acid |
| Chlorogenate |
| (1S,3R,4R,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid |
| 3-Caffeoylquinate |
| 5-caffeoylquinic acid |
| 3-O-Caffeoylquinic acid |
| 3-Caffeoylquinic acid |
| CHLOROGENIC ACID |
| Chlorogenic acid,predominantly trans,from coffee seeds |
| 3-(3,4-Dihydroxycinnamoyl)quinic Acid Hydrate |
| Heriguard |
| EINECS 206-325-6 |
| 3-mono-O-caffeoylquinic acid |
| MFCD00003862 |
