CAS 143-07-7|Lauric acid
Introduction：Basic information about CAS 143-07-7|Lauric acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lauric acid | ||
|---|---|---|---|
| CAS Number | 143-07-7 | Molecular Weight | 200.318 |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 296.1±3.0 °C at 760 mmHg |
| Molecular Formula | C12H24O2 | Melting Point | 44-46 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 134.1±11.9 °C |
| Symbol | GHS05 | Signal Word | Danger |
Names
| Name | dodecanoic acid |
|---|---|
| Synonym | More Synonyms |
Lauric acid BiologicalActivity
| Description | Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialNatural Products >>Acids and AldehydesResearch Areas >>Infection |
| Target | Human Endogenous Metabolite |
| References | [1]. Nakatsuji T, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009 Oct;129(10):2480-8. |
Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 296.1±3.0 °C at 760 mmHg |
| Melting Point | 44-46 °C(lit.) |
| Molecular Formula | C12H24O2 |
| Molecular Weight | 200.318 |
| Flash Point | 134.1±11.9 °C |
| Exact Mass | 200.177628 |
| PSA | 37.30000 |
| LogP | 5.03 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.448 |
| Stability | Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents. |
| Water Solubility | insoluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 131 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 333 gm/kg/13W-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Behavioral - fluid intake
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 108 gm/kg/15W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Tumorigenic - active as anti-cancer agent
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 294,263,1981 *** REVIEWS *** TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84696 No. of Facilities: 1256 (estimated) No. of Industries: 14 No. of Occupations: 34 No. of Employees: 14960 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84696 No. of Facilities: 4690 (estimated) No. of Industries: 51 No. of Occupations: 50 No. of Employees: 77970 (estimated) No. of Female Employees: 17300 (estimated)
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 294,263,1981 *** REVIEWS *** TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84696 No. of Facilities: 1256 (estimated) No. of Industries: 14 No. of Occupations: 34 No. of Employees: 14960 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84696 No. of Facilities: 4690 (estimated) No. of Industries: 51 No. of Occupations: 50 No. of Employees: 77970 (estimated) No. of Female Employees: 17300 (estimated)
Safety Information
| Symbol | GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H318 |
| Precautionary Statements | P280-P305 + P351 + P338 + P310 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/38 |
| Safety Phrases | S37/39-S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | OE9800000 |
| HS Code | 2916399090 |
Customs
| HS Code | 2915900090 |
|---|---|
| Summary | 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| EINECS 205-582-1 |
| Lauric acid |
| MFCD00002736 |
| Dodecanoic Acid |
