Introduction：Basic information about CAS 501-30-4|kojic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | kojic acid |
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| CAS Number | 501-30-4 | Molecular Weight | 142.11 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 401.7±45.0 °C at 760 mmHg |
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| Molecular Formula | C6H6O4 | Melting Point | 152-155 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 179.9±22.2 °C |
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Names
| Name | kojic acid |
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| Synonym | More Synonyms |
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kojic acid BiologicalActivity
| Description | Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>Others |
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| References | [1]. Wei X, et al. Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways. Exp Eye Res. 2018 Dec 28;180:174-183. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 401.7±45.0 °C at 760 mmHg |
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| Melting Point | 152-155 °C(lit.) |
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| Molecular Formula | C6H6O4 |
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| Molecular Weight | 142.11 |
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| Flash Point | 179.9±22.2 °C |
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| Exact Mass | 142.026611 |
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| PSA | 70.67000 |
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| LogP | -0.64 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.607 |
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| InChIKey | BEJNERDRQOWKJM-UHFFFAOYSA-N |
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| SMILES | O=c1cc(CO)occ1O |
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| Storage condition | Refrigerator |
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| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
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| Water Solubility | SOLUBLE |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UQ0875000
- CHEMICAL NAME :
- 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-
- CAS REGISTRY NUMBER :
- 501-30-4
- BEILSTEIN REFERENCE NO. :
- 0120895
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C6-H6-O4
- MOLECULAR WEIGHT :
- 142.12
- WISWESSER LINE NOTATION :
- T6O DVJ B1Q EQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 4500 mg/L
- REFERENCE :
- TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 59,213,1991
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xn |
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| Risk Phrases | R40 |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | UQ0875000 |
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| HS Code | 29329995 |
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Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Articles117
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Synonyms
| 2-(hydroxymethyl)-5-hydroxy-4H-pyran-4-one |
| 5-hydroxy-2-(hydroxymethyl)pyran-4-one |
| UNII-6K23F1TT52 |
| 5-Hydroxy-2-(hydroxymethyl)-4-pyrone |
| 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone |
| 2-Hydroxymethyl-5-hydroxy-γ-pyrone |
| MFCD00006580 |
| 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one |
| 4H-PYRAN-4-ONE,5-HYDROXY-2-(HYDROXYMETHYL) |
| 5-hydroxy-2-(hydroxmetyl)-4H-pyran-4-one |
| 3-hydroxy-6-hydroxymethyl-4H-pyran-4-one |
| EINECS 207-922-4 |
