Introduction：Basic information about CAS 7460-82-4|Diethylene glycol bis(p-toluenesulfonate), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Diethylene glycol bis(p-toluenesulfonate) |
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| CAS Number | 7460-82-4 | Molecular Weight | 414.493 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 581.2±45.0 °C at 760 mmHg |
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| Molecular Formula | C18H22O7S2 | Melting Point | 87-89 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 305.3±28.7 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | Oxybis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 581.2±45.0 °C at 760 mmHg |
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| Melting Point | 87-89 °C(lit.) |
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| Molecular Formula | C18H22O7S2 |
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| Molecular Weight | 414.493 |
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| Flash Point | 305.3±28.7 °C |
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| Exact Mass | 414.080688 |
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| PSA | 112.73000 |
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| LogP | 2.70 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.554 |
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| InChIKey | VYVPNTJBGPQTFA-UHFFFAOYSA-N |
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| SMILES | Cc1ccc(S(=O)(=O)OCCOCCOS(=O)(=O)c2ccc(C)cc2)cc1 |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2904100000 |
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Customs
| HS Code | 2904100000 |
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| Summary | 2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Articles1
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Synonyms
| Ethanol, 2,2'-oxybis-, bis(4-methylbenzenesulfonate) |
| Oxydi-2,1-ethanediyl bis(4-methylbenzenesulfonate) |
| oxydiethane-2,1-diyl bis(4-methylbenzenesulfonate) |
| MFCD00026001 |
| 2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethyl 4-methylbenzenesulfonate |
