CAS 816-94-4|1,2-Distearoyl-sn-glycero-3-phosphocholine
| Common Name | 1,2-Distearoyl-sn-glycero-3-phosphocholine | ||
|---|---|---|---|
| CAS Number | 816-94-4 | Molecular Weight | 790.145 |
| Density | / | Boiling Point | / |
| Molecular Formula | C44H88NO8P | Melting Point | 236 °C |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | 1,2-distearoyl-sn-glycero-3-phosphocholine |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | In empty lipid nanoparticle (LNP) systems that do not contain siRNA, DSPC-cholesterol resides in outer layers, whereas in loaded systems a portion of the DSPC-cholesterol is internalised together with siRNA[2]. |
| References | [1]. Andrew D Miller. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811. [2]. Jayesh A Kulkarni, et al. On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739. |
Chemical & Physical Properties
| Melting Point | 236 °C |
|---|---|
| Molecular Formula | C44H88NO8P |
| Molecular Weight | 790.145 |
| Exact Mass | 789.624756 |
| PSA | 121.00000 |
| LogP | 13.00 |
| InChIKey | NRJAVPSFFCBXDT-HUESYALOSA-N |
| SMILES | CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
Articles54
More Articles| Immunoliposomes containing Soluble Leishmania Antigens (SLA) as a novel antigen delivery system in murine model of leishmaniasis. Exp. Parasitol. 146 , 78-86, (2014) Development of new generation of vaccines against leishmaniasis requires adjuvants to elicit the type and intensity of immune response needed for protection. The coupling of target-specific antibodies... | |
| Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome. J. Lipid Res. 55(12) , 2509-20, (2014) To evaluate functional and compositional properties of HDL in subjects from a kindred of genetic apoA-I deficiency, two homozygotes and six heterozygotes, with a nonsense mutation at APOA1 codon -2, Q... | |
| Ultrasound triggered drug delivery with liposomal nested microbubbles. Ultrasonics 63 , 31-8, (2015) When ultrasound contrast agent microbubbles are nested within a liposome, damage to the liposome membrane caused by both stable and inertial cavitation of the microbubble allows for release of the aqu... |
Synonyms
| EINECS 212-440-2 |
| MFCD00036905 |
| (2R)-2,3-Bis(stearoyloxy)propyl 2-(trimethylammonio)ethyl phosphate |
| 1,2-Distearoyl-sn-glycero-3-phosphocholine |
| Ethanaminium, 2-[[[(2R)-2,3-bis[(1-oxooctadecyl)oxy]propoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, inner salt |
| (2R)-2,3-bis(octadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate |
| L-α-PHOSPHATIDYLCHOLINE, DISTEAROYL |
