CAS 41443-28-1|ODQ
| Common Name | ODQ | ||
|---|---|---|---|
| CAS Number | 41443-28-1 | Molecular Weight | 187.155 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 321.3±25.0 °C at 760 mmHg |
| Molecular Formula | C9H5N3O2 | Melting Point | 160-170 °C |
| MSDS | ChineseUSA | Flash Point | 148.1±23.2 °C |
Names
| Name | [1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one |
|---|---|
| Synonym | More Synonyms |
ODQ BiologicalActivity
| Description | ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Guanylate Cyclase |
| In Vitro | At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM[1]. |
| In Vivo | ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat[2]. Animal Model: Anesthetized, male Wistar rats[2] Dosage: 2 mg/kg Administration: I.p. Result: Attenuated the renal dysfunction, lung injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide. |
| References | [1]. Ronald Fiscus, et al. ODQ, an inhibitor of soluble guanylyl cyclase (nitric oxide-activated enzyme), enhances the pro-apoptotic effects of cisplatin in human mesothelioma cells. Cancer Res May 1 2007 (67) (9 Supplement) LB-43. [2]. Zacharowski K, et al. The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock. Crit Care Med. 2001;29(8):1599-1608. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 321.3±25.0 °C at 760 mmHg |
| Melting Point | 160-170 °C |
| Molecular Formula | C9H5N3O2 |
| Molecular Weight | 187.155 |
| Flash Point | 148.1±23.2 °C |
| Exact Mass | 187.038177 |
| PSA | 60.40000 |
| LogP | 0.28 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.781 |
| InChIKey | LZMHWZHOZLVYDL-UHFFFAOYSA-N |
| SMILES | O=c1onc2cnc3ccccc3n12 |
| Storage condition | 2-8°C |
| Water Solubility | ethanol: 1.2 mg/mL |
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles59
More Articles| Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation. BMC Cancer 15 , 17, (2015) DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in ant... | |
| Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension. PLoS ONE 10 , e0134876, (2015) Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-c... | |
| Isosorbide dinitrate inhibits mechanical stress-induced cardiac hypertrophy and autophagy through downregulation of angiotensin II type 1 receptor. J. Cardiovasc. Pharmacol. 65(1) , 1-7, (2015) Mechanical stress can induce cardiac hypertrophy and autophagy. Recently, it has been reported that nitric oxide donors inhibited autophagy in human chondrocytes. Therefore, the effect of isosorbide d... |
Synonyms
| [1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one |
| Lopac-O-3636 |
| T B566 BNVON HNJ |
| 1H-[1,2,4]oxadiazolol[4,3,-a]quinoxalin-1-one |
| Tocris-0880 |
| 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one |
| MFCD00792620 |
| 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one |
| ODQ |
| 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one |
| 1-H-[1,2,4]Oxadiazolo-[4,3,2]quinoxalin-1-ine |
