CAS 486-64-6|Vasicinone

Introduction：Basic information about CAS 486-64-6|Vasicinone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameVasicinone
CAS Number486-64-6Molecular Weight202.209
Density1.5±0.1 g/cm3Boiling Point409.8±47.0 °C at 760 mmHg
Molecular FormulaC11H10N2O2Melting Point200-202ºC
MSDS/Flash Point201.7±29.3 °C

Names

Namevasicinone
SynonymMore Synonyms

Vasicinone BiologicalActivity

DescriptionVasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1].
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
In VitroVasicinone (1~30 µM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability[1]. Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death[1]. Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells Concentration: 1~30 µM Incubation Time: 24 hours Result: Significantly reversed the paraquat-induced reduction in cell viability. Western Blot Analysis[1] Cell Line: SH-SY5Y cells Concentration: 10 and 15 µM Incubation Time: 24 hours Result: Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway. Apoptosis Analysis[1] Cell Line: SH-SY5Y cells Concentration: 10 and 15 µM Incubation Time: 24 hours Result: Dose-dependently reduced the percentage of apoptotic cells.
References

[1]. Ju DT, et al. Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson's Disease-Associated SH-SY5Y Cell Model. Nutrients. 2019;11(7):1655. Published 2019 Jul 19.

Chemical & Physical Properties

Density1.5±0.1 g/cm3
Boiling Point409.8±47.0 °C at 760 mmHg
Melting Point200-202ºC
Molecular FormulaC11H10N2O2
Molecular Weight202.209
Flash Point201.7±29.3 °C
Exact Mass202.074234
PSA55.12000
LogP-0.40
Vapour Pressure0.0±1.0 mmHg at 25°C
Index of Refraction1.743
InChIKeySDIVYZXRQHWCKF-VIFPVBQESA-N
SMILESO=c1c2ccccc2nc2n1CCC2O
Storage condition2-8℃

Safety Information

Hazard CodesXi

Synonyms

(3S)-3-Hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Pyrrolo[2,1-b]quinazolin-9(1H)-one, 2,3-dihydro-3-hydroxy-, (3S)-
Vasicinone
L-vasicinone
CAS 134099-24-4|2,6-Difluoro-3-(trifluoromethyl)benzaldehyde
CAS 63285-98-3|2-Methyl-5-oxo-4-phenyl-2,5-dihydroisoxazole-3-carboxylic acid
Recommended......
CAS 489437-72-1|1-N-Boc-4-N-Be CAS 4870-31-9|5-anilino-1H-pyr CAS 489451-29-8|6-BROMO-2-(3-I CAS 485831-34-3|1,4-Benzenedia CAS 486427-17-2|CIQ CAS 480439-31-4|phenyl-(2,3,4- CAS 486-79-3|Dipyrocetyl CAS 4875-10-9|2-Nitrothiopheno CAS 486422-70-2|4-(4-Ethylpipe CAS 4815-25-2|methyl 2-amino-4 CAS 488-87-9|2,5-DIMETHYLRESOR CAS 480425-36-3|n-[2-(4,4,5,5- CAS 480438-75-3|4-(tert-Butoxy CAS 48108-93-6|2-(2-Aminoethyl CAS 4856-87-5|1,1'-hexane- CAS 483-18-1|Emetine CAS 4837-19-8|3-(Difluorometho CAS 4848-04-8|2-(2-phenylethyl CAS 4874-36-6|5-mercaptomethyl CAS 480424-54-2|(2-ethoxy-3-fo
Disclaimer

This site is a non-commercial website, not accept any sponsorship and advertising. The content is collated from the Internet, does not represent the position of this site, for personal reference only, please distinguish by yourself! The belongs to the original author.

Copyright © 2025 All Rights Reserved.

TOP