Introduction：Basic information about CAS 2284-31-3|Pratensein, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pratensein |
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| CAS Number | 2284-31-3 | Molecular Weight | 300.26300 |
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| Density | 1.512g/cm3 | Boiling Point | 576.7ºC at 760mmHg |
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| Molecular Formula | C16H12O6 | Melting Point | 271-273 °C |
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| MSDS | / | Flash Point | 220.3ºC |
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Names
| Name | pratensein |
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| Synonym | More Synonyms |
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Pratensein BiologicalActivity
| Description | Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels[1]. |
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| Related Catalog | Research Areas >>Neurological Disease |
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| In Vivo | Pratensein significantly attenuates neuronal degeneration and apoptosis in hippocampus. The over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 are significantly reduced following administration of Pratensein. Pratensein treatment significantly suppresses the activation of NF-κB in hippocampus. Pratensein is able to increase the levels of synaptophysin and brain-derived neurotrophic factor (BDNF)[1]. Pratensein (20 mg/kg; p.o.; once daily for 3 weeks) ameliorates learning and memory deficits in Aβ1-42 rat model of Alzheimer’s disease[1]. Animal Model: Male 10-week old Wistar rats[1] Dosage: 20 mg/kg Administration: P.o.; once daily for 3 weeks Result: The spatial learning and memory ability of rats was improved. |
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| References | [1]. Liang C, et al. Pratensein ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels. Neurosci Lett. 2015;592:48-53. |
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Chemical & Physical Properties
| Density | 1.512g/cm3 |
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| Boiling Point | 576.7ºC at 760mmHg |
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| Melting Point | 271-273 °C |
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| Molecular Formula | C16H12O6 |
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| Molecular Weight | 300.26300 |
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| Flash Point | 220.3ºC |
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| Exact Mass | 300.06300 |
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| PSA | 100.13000 |
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| LogP | 2.58540 |
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| Vapour Pressure | 6.73E-14mmHg at 25°C |
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| Index of Refraction | 1.697 |
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| InChIKey | FPIOBTBNRZPWJW-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2coc3cc(O)cc(O)c3c2=O)cc1O |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2914509090 |
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 5,7,3'-trihydroxy-4'-methoxyisoflavone |
| 5,7-dihydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one |
| 3',5,7-trihydroxy-4'-methoxyisoflavone |
| Pratensein |
| 5,7,5'-trihydroxy-4'-methoxyisoflavone |
| 3'-hydroxy-biochanin A |
