CAS 173075-45-1|(24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid

Introduction：Basic information about CAS 173075-45-1|(24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name(24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid
CAS Number173075-45-1Molecular Weight468.668
Density1.1±0.1 g/cm3Boiling Point602.1±55.0 °C at 760 mmHg
Molecular FormulaC30H44O4Melting Point/
MSDS/Flash Point332.0±28.0 °C

Names

Nameganoderic acid dm
SynonymMore Synonyms

BiologicalActivity

DescriptionGanoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].
Related CatalogSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>PI3KResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease
In VitroGanoderic acid DM (GADM) effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells[1]. Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). Ganoderic acid DM markedly suppressed the expression of cathepsin K and TRAP mRNA[2]. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity[3]. Cell Viability Assay[1] Cell Line: MCF-7 and MDA-MB-231 cells. Concentration: 0-100 μM. Incubation Time: 48 h. Result: Decreased the cell viability in breast cancer cells. Cell Viability Assay[2] Cell Line: RAW-D cells. Concentration: 0-100 μg/mL. Incubation Time: 0-100 μg/mL. Result: Clearly suppressed osteoclastogenesis from the RAW 264 cell D-clone.
References

[1]. Guo-Sheng Wu, et al. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012 Mar;83(2):408-14.

[2]. Ichiko Miyamoto, et al. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. Eur J Pharmacol. 2009 Jan 5;602(1):1-7.

[3]. Junbo Xia, et al. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity. Chem Biol Interact. 2020 Jan 25;316:108932.

Chemical & Physical Properties

Density1.1±0.1 g/cm3
Boiling Point602.1±55.0 °C at 760 mmHg
Molecular FormulaC30H44O4
Molecular Weight468.668
Flash Point332.0±28.0 °C
Exact Mass468.323975
PSA71.44000
LogP6.90
Vapour Pressure0.0±3.7 mmHg at 25°C
Index of Refraction1.547
InChIKeyZTKZZRIVAYGFSF-LYWQSRDLSA-N
SMILESCC(=CCCC(C)C1CCC2(C)C3=C(CCC12C)C1(C)CCC(=O)C(C)(C)C1CC3=O)C(=O)O

Safety Information

Hazard CodesXi

Synonyms

Gaderic acid DM
Lanosta-8,24-dien-26-oic acid, 3,7-dioxo-, (24E)-
(24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid
CAS 96853-23-5|Methyl 6-chloro-2-(methylamino)-3-nitrobenzoate
CAS 529-51-1|Azaleatin
Recommended......
CAS 175202-26-3|3-CHLORO-4-(IS CAS 17264-88-9|SODIUM 3-CHLORO CAS 175202-68-3|2-(4-BROMO-3,5 CAS 17540-75-9|4-sec-Butyl-2,6 CAS 1738-82-5|H-Gly-Gly-OBzl & CAS 17355-10-1|Tyrosylleucine CAS 175278-22-5|4-Amino-3-(tri CAS 173424-77-6|1-[2-chloroeth CAS 17723-32-9|3,5-Dichloro-2, CAS 1703-51-1|2,5-Heptanedione CAS 173336-82-8|2-(ETHYLSULFON CAS 17887-62-6|Dimethylphenyls CAS 17070-69-8|Dichloro(3-isoc CAS 178065-30-0|N2-(5-Fluoro-2 CAS 17321-20-9|3-Chloro-6-etho CAS 17373-28-3|1-Undecanamine, CAS 17309-13-6|ethyl 4-methyl- CAS 1778-08-1|Benzamide,2-hydr CAS 1759-05-3|bis(4-chloro-3-n CAS 1759-58-6|1,3-Dimethylcycl
Disclaimer

This site is a non-commercial website, not accept any sponsorship and advertising. The content is collated from the Internet, does not represent the position of this site, for personal reference only, please distinguish by yourself! The belongs to the original author.

Copyright © 2025 All Rights Reserved.

TOP