CAS 1132-68-9|4-Fluoro-Phe-OH

Introduction：Basic information about CAS 1132-68-9|4-Fluoro-Phe-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 4-Fluoro-Phe-OH BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles5
6. Synonyms

Common Name	4-Fluoro-Phe-OH
CAS Number	1132-68-9	Molecular Weight	183.180
Density	1.3±0.1 g/cm3	Boiling Point	313.3±32.0 °C at 760 mmHg
Molecular Formula	C₉H₁₀FNO₂	Melting Point	~255 °C (dec.)
MSDS	ChineseUSA	Flash Point	143.3±25.1 °C

Names

Name	4-fluorophenyl-L-alanine
Synonym	More Synonyms

4-Fluoro-Phe-OH BiologicalActivity

Description	p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli (KD=0.26 μM)[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Luck LA, et al. Fluorescence and 19F NMR evidence that phenylalanine, 3-L-fluorophenylalanine and 4-L-fluorophenylalanine bind to the L-leucine specific receptor of Escherichia coli. Protein Sci. 2000;9(12):2573-2576. [2]. Hillas PJ, et al. A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines. Biochemistry. 1996;35(22):6969-6975. [3]. Luck LA, et al. Fluorescence and 19F NMR evidence that phenylalanine, 3-L-fluorophenylalanine and 4-L-fluorophenylalanine bind to the L-leucine specific receptor of Escherichia coli. Protein Sci. 2000;9(12):2573-2576.

Description

p-Fluoro-L-phenylalanine (4-Fluoro-L-phenylalanine) is a substrate for tyrosine hydroxylase (TH) that can be used to study the regulation of that enzyme. p-Fluoro-L-phenylalanine binds to the L-leucine specific receptor of Escherichia coli (KD=0.26 μM)[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Luck LA, et al. Fluorescence and 19F NMR evidence that phenylalanine, 3-L-fluorophenylalanine and 4-L-fluorophenylalanine bind to the L-leucine specific receptor of Escherichia coli. Protein Sci. 2000;9(12):2573-2576.

[2]. Hillas PJ, et al. A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines. Biochemistry. 1996;35(22):6969-6975.

[3]. Luck LA, et al. Fluorescence and 19F NMR evidence that phenylalanine, 3-L-fluorophenylalanine and 4-L-fluorophenylalanine bind to the L-leucine specific receptor of Escherichia coli. Protein Sci. 2000;9(12):2573-2576.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	313.3±32.0 °C at 760 mmHg
Melting Point	~255 °C (dec.)
Molecular Formula	C₉H₁₀FNO₂
Molecular Weight	183.180
Flash Point	143.3±25.1 °C
Exact Mass	183.069550
PSA	63.32000
LogP	1.16
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.555
InChIKey	XWHHYOYVRVGJJY-QMMMGPOBSA-N
SMILES	NC(Cc1ccc(F)cc1)C(=O)O

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S23-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DW1765000

Articles5

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

Regulation of rat liver phenylalanine hydroxylase. I. Kinetic properties of the enzyme's iron and enzyme reduction site.

J. Biol. Chem. 269 , 24637, (1994)

Tetrahydropterins react with phenylalanine hydroxylase at a redox site, a regulatory site, and the catalytic site, but neither the properties of nor relationships among these sites are well understood...

Synonyms

L-4-FLUOROPHE

(2R)-2-Amino-3-(4-fluorophenyl)propanoic acid

D,L-p-fluorophenylalanine

L-4-F-Phe-OH

L-p-fluorophenylalanine

4-Fluorophenylalanine

H-Phe(4-F)-OH

H-L-PHE(4-F)-OH

L-4-Fluorophenylalanine

4-fluoroPhe

RARECHEM BK PT 0031

(2R)-2-amino-3-(4-fluorophenyl)propionic acid

D-4-Fluorophenylalanine

Phenylalanine, 4-fluoro-

para-fluoro-l-phenylalanine

H-PHE(P-F)-OH

D-4-Fluorophe

H-P-FLUORO-PHE-OH

(S)-2-Amino-3-(4-fluorophenyl)propanoic acid

4-Fluoro-Phe-OH

MFCD00063064

S-(-)-p-Fluorophenylalanine

para-fluorophenylalanine

p-Fluoro-L-phenylalanine

L-4-Fluoro-Phenylalanine

D,L-4-fluorophenylalanine

L-4-Fluoro-phe-OH

(2S)-2-amino-3-(4-fluorophenyl)propanoic acid

H-D-Phe(4-F)-OH

(S)-4-Fluorophenylalanine

4-Fluoro-L-phenylalanine

(S)-2-Amino-3-(4-fluorophenyl)propionic Acid

4-FLUOROPHENYLALANINE, D-

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