Introduction：Basic information about CAS 95153-31-4|Perindoprilat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Perindoprilat |
|---|
| CAS Number | 95153-31-4 | Molecular Weight | 340.415 |
|---|
| Density | 1.2±0.1 g/cm3 | Boiling Point | 568.1±45.0 °C at 760 mmHg |
|---|
| Molecular Formula | C17H28N2O5 | Melting Point | 153-155ºC |
|---|
| MSDS | / | Flash Point | 297.4±28.7 °C |
|---|
Names
| Name | (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid |
|---|
| Synonym | More Synonyms |
|---|
Perindoprilat BiologicalActivity
| Description | Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2]. |
|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE) |
|---|
| In Vitro | Perindoprilat (1 μM, 10 days) treatment suppresses the angiotensin II production in HNSCC cells[3]. Cell Viability Assay[3] Cell Line: HNSCC cells Concentration: 1 μM Incubation Time: 10 days Result: Suppressed the angiotensin II production in HNSCC cells (P=0.028). |
|---|
| References | [1]. Perindopril. Expert Opin Pharmacother. 2006 Jan;7(1):63-71. [2]. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6. |
|---|
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|
| Boiling Point | 568.1±45.0 °C at 760 mmHg |
|---|
| Melting Point | 153-155ºC |
|---|
| Molecular Formula | C17H28N2O5 |
|---|
| Molecular Weight | 340.415 |
|---|
| Flash Point | 297.4±28.7 °C |
|---|
| Exact Mass | 340.199829 |
|---|
| PSA | 106.94000 |
|---|
| LogP | 2.37 |
|---|
| Vapour Pressure | 0.0±3.4 mmHg at 25°C |
|---|
| Index of Refraction | 1.535 |
|---|
| InChIKey | ODAIHABQVKJNIY-PEDHHIEDSA-N |
|---|
| SMILES | CCCC(NC(C)C(=O)N1C(C(=O)O)CC2CCCCC21)C(=O)O |
|---|
| Storage condition | -20°C Freezer |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NL6007250
- CHEMICAL NAME :
- 1H-Indole-2-carboxylic acid, octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl)-, (2S-(1(R*(R*)),2-alpha,3a-beta,7a-beta))-
- CAS REGISTRY NUMBER :
- 95153-31-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C17-H28-N2-O5
- MOLECULAR WEIGHT :
- 340.47
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 10,446,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 10,446,1992
|
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Synonyms
| (2S-(1(R*(R*)),2a,3ab,7ab))-Octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl)-1H-indole-2-carboxylic Acid |
| (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid |
| Perindoprilat |
| (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]-propanoyl]octahydro-1H-indole-2-carboxylic acid |
| (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-Carboxybutyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid |
| S-9780 |
| Perindoprilato [Spanish] |
| Perindoprilate [French] |
| UNII-2UV6ZNQ92K |
| Perindoprilatum [Latin] |
