CAS 22560-50-5|Clodronate Disodium
Introduction：Basic information about CAS 22560-50-5|Clodronate Disodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Clodronate Disodium | ||
|---|---|---|---|
| CAS Number | 22560-50-5 | Molecular Weight | 288.856 |
| Density | 2.306g/cm3 | Boiling Point | 474.7ºC at 760mmHg |
| Molecular Formula | CH2Cl2Na2O6P2 | Melting Point | >330ºC |
| MSDS | USA | Flash Point | 240.9ºC |
Names
| Name | clodronic acid disodium salt |
|---|---|
| Synonym | More Synonyms |
Clodronate Disodium BiologicalActivity
| Description | Clodronic acid (Clodronate) disodium salt, a first-generation bisphosphonate, is orally active osteoclastic bone resorption inhibitor. Clodronic acid disodium salt can be used in high bone turnover states, Paget’s disease and osteolytic bone metastases[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| In Vitro | Clodronic acid (Clodronate) disodium salt induces rapid apoptosis in osteoclasts by preventing translocation of ADP into mitochondria after being internalised via resorption. Consequently, ATP production is inhibited, leading to induction of apoptosis by means of release of cytochrome C into the cytoplasm[2]. |
| In Vivo | Clodronic acid (Clodronate) disodium salt (6.25-25 mg/kg; p.o.; daily for 28 days) slightly decreases the hindpaw swelling at doses of 12.5 and 25 mg/kg[3]. Animal Model: Male Lewis rats, aged 7 weeks[3] Dosage: 6.25, 12.5, and 25 mg/kg Administration: P.o.; daily for 28 days Result: Hindpaw swelling was significantly smaller than in adjuvant-arthritis (AA)-control at 25 mg/kg on days 21 and 28 (87 and 88% of AA-control, respectively) and at 12.5 mg/kg on day 28. |
| References | [1]. Mönkkönen J, et al. Clodronate (dichloromethylene bisphosphonate) inhibits LPS-stimulated IL-6 and TNF production by RAW 264 cells. Life Sci. 1994;54(14):PL229‐PL234. [2]. Tanakol R, et al. Clodronic acid in the treatment of postmenopausal osteoporosis. Clin Drug Investig. 2007;27(6):419‐433. [3]. Itoh F, et al. Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis. Inflammation. 2004;28(1):15‐21. |
Chemical & Physical Properties
| Density | 2.306g/cm3 |
|---|---|
| Boiling Point | 474.7ºC at 760mmHg |
| Melting Point | >330ºC |
| Molecular Formula | CH2Cl2Na2O6P2 |
| Molecular Weight | 288.856 |
| Flash Point | 240.9ºC |
| Exact Mass | 287.849915 |
| PSA | 140.34000 |
| LogP | 1.30710 |
| Vapour Pressure | 2.55E-10mmHg at 25°C |
| InChIKey | HJKBJIYDJLVSAO-UHFFFAOYSA-J |
| SMILES | O=P([O-])([O-])C(Cl)(Cl)P(=O)([O-])[O-].[Na+].[Na+] |
| Storage condition | -20°C Freezer |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3600 mg/kg/15D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1200 mg/kg/3D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,27,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - pig
- DOSE/DURATION :
- 182 gm/kg/26W-I
- TOXIC EFFECTS :
- Musculoskeletal - changes in teeth and supporting structures Musculoskeletal - other changes Related to Chronic Data - death
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 59,129,1986
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | SZ7640700 |
| HS Code | 2931900090 |
Customs
| HS Code | 2931900090 |
|---|---|
| Summary | 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Clastoban |
| Clodronic acid disodium salt |
| Cl2MDP Clodronate disodium Clodronic acid disodium salt DMDP |
| Bonefos |
| UNII-Y05R4GCQ1H |
| (Dichloromethylene)diphosphonic acid,disodium salt |
| Phosphonic acid, (dichloromethylene)bis-, sodium salt (1:2) |
| EINECS 245-078-9 |
| MFCD01632786 |
| Clasteon |
| Lytos |
| Ossiten |
| Sodium clodronate |
| disodium,[dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate |
| Loron |
| Disodium Clodronate |
| Mebonat |
| Clodronate Disodium |
| Clodronic Acid, Disodium Salt, Hydrate |
| disodium (dichloromethanediyl)bis[hydrogen (phosphonate)] |
| Disodium (dichloromethylene)bis[hydrogen (phosphonate)] |
| Ostac |
| Dichloromethylenediphosphonic acid disodium salt |
