Introduction：Basic information about CAS 1218-98-0|7,8-Dihydroneopterin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 7,8-Dihydroneopterin |
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| CAS Number | 1218-98-0 | Molecular Weight | 255.23100 |
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| Density | 2.03g/cm3 | Boiling Point | 614.6ºC at 760mmHg |
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| Molecular Formula | C9H13N5O4 | Melting Point | / |
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| MSDS | / | Flash Point | 325.5ºC |
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Names
| Name | 7,8-dihydroneopterin |
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| Synonym | More Synonyms |
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7,8-Dihydroneopterin BiologicalActivity
| Description | 7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisSignaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
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| Target | Apoptosis; iNOS[1] |
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| In Vitro | 7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y)[1]. 7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes[1] . Cell Viability Assay[1] Cell Line: Astrocytic cell line U373MG Concentration: 0.1, 0.5, 1, 2.5, 5 mM Incubation Time: 2 days and 5 days Result: After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM. After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium. A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth. |
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| References | [1]. C Speth, et al. Inflammation Marker 7,8-dihydroneopterin Induces Apoptosis of Neurons and Glial Cells: A Potential Contribution to Neurodegenerative Processes. Immunobiology. 2000 Nov;202(5):460-76. |
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Chemical & Physical Properties
| Density | 2.03g/cm3 |
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| Boiling Point | 614.6ºC at 760mmHg |
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| Molecular Formula | C9H13N5O4 |
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| Molecular Weight | 255.23100 |
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| Flash Point | 325.5ºC |
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| Exact Mass | 255.09700 |
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| PSA | 156.85000 |
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| Vapour Pressure | 1.13E-17mmHg at 25°C |
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| Index of Refraction | 1.86 |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26;S36 |
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Synonyms
| 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine |
| 2-amino-6-(1,2,3-trihydroxy-propyl)-7,8-dihydro-3H-pteridin-4-one |
| 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one |
| 2-amino-4-hydroxy-6-(D-erythro)-trihydroxypropyldihydropteridin |
| 7,8-dihydroeopterin |
| 7,8-dihydro-D-neopterin |
| dihydro-7,8-D-neopterine |
| Neopterin,7,8-dihydro |
| 2-Amino-4-hydroxy-6-<D-erythro-1'.2'.3'-trihydroxy-propyl>-pteridin-10-C14 |
| 2-Amino-7,8-dihydro-6-(1,2,3-trihydroxypropyl)-4(1H)-pteridinone |
| MFCD00049358 |
| 7,8-Dihydroneopterin |
| Dihydroneopterin |
