Introduction：Basic information about CAS 18865-48-0|Actinomycin X2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Actinomycin X2 |
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| CAS Number | 18865-48-0 | Molecular Weight | 1269.40000 |
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| Density | 1.44g/cm3 | Boiling Point | 1411.4ºC at 760mmHg |
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| Molecular Formula | C62H84N12O17 | Melting Point | / |
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| MSDS | / | Flash Point | 807.4ºC |
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Names
| Name | actinomycin v |
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| Synonym | More Synonyms |
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Actinomycin X2 BiologicalActivity
| Description | Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| References | [1]. Zhiyu Chen, et al. Anti-MRSA Activity of Actinomycin X 2 and Collismycin A Produced by Streptomyces globisporusWA5-2-37 From the Intestinal Tract of American Cockroach ( Periplaneta americana). Front Microbiol. 2020 Apr 7;11:555. |
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Chemical & Physical Properties
| Density | 1.44g/cm3 |
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| Boiling Point | 1411.4ºC at 760mmHg |
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| Molecular Formula | C62H84N12O17 |
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| Molecular Weight | 1269.40000 |
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| Flash Point | 807.4ºC |
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| Exact Mass | 1268.61000 |
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| PSA | 377.05000 |
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| LogP | 1.55260 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.661 |
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| InChIKey | GQZJMUMSSGCVFS-JUTCBMOCSA-N |
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| SMILES | Cc1c2oc3c(C)ccc(C(=O)NC4C(=O)NC(C(C)C)C(=O)N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)c3nc-2c(C(=O)NC2C(=O)NC(C(C)C)C(=O)N3CC(=O)CC3C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC2C)c(N)c1=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AU2010000
- CHEMICAL NAME :
- Actinomycin X2
- CAS REGISTRY NUMBER :
- 18865-48-0
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C62-H84-N12-O17
- MOLECULAR WEIGHT :
- 1269.58
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1625,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,427,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(2),48,1980
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Safety Information
| Hazard Codes | T+: Very toxic; |
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| Risk Phrases | 26/27/28-63 |
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| Safety Phrases | 22-36/37/39-45 |
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| RIDADR | UN 2811 6.1/PG 2 |
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Synonyms
| 5'-Deoxy(Methylthio-d3)adenosine |
| 3h-phenoxazine,actinomycindderiv. |
| [A3-(4-oxo-L-proline)]-actinomycin-D |
| 5'-S-(Methyl-d3)thioadenosine |
| 3a-(4-oxo-l-proline)-actinomycin |
| 5'-(Methylthio-d3)adenosine |
| actinomycin-V |
| ACTINOMYCIN X2 |
