CAS 119386-39-9|LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2
Introduction：Basic information about CAS 119386-39-9|LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2 | ||
|---|---|---|---|
| CAS Number | 119386-39-9 | Molecular Weight | 987.16100 |
| Density | / | Boiling Point | / |
| Molecular Formula | C40H78N18O11 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | h-lys-lys-arg-ala-ala-arg-ala-thr-ser-nh2 |
|---|---|
| Synonym | More Synonyms |
LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2 BiologicalActivity
| Description | Myosin light chain kinase fragment 11-19 amide (MLCK(11-19) amide) is a substrate-specific peptide inhibitor of MLCK. Myosin light chain kinase fragment 11-19 amide inhibits hypotonicity-induced Ca2+ entry. Myosin light chain kinase fragment 11-19 amide can be used in the research of human cervical cancer[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
| Target | MLCK[1] |
| In Vitro | Myosin light chain kinase fragment 11-19 amide (5 μM) reduces the amplitude and rate of activation of noradrenaline-evoked non-selective cation current (Icat) in rabbit portal vein myocytes[1]. Myosin light chain kinase fragment 11-19 amide inhibits swelling-activated taurine transport with an IC50 value of 2.0 µM[2]. Myosin light chain kinase fragment 11-19 amide (10 µM) inhibits β2-integrin-mediated adhesion in neutrophils treated with KT5720 (25 µM)[3]. |
Chemical & Physical Properties
| Molecular Formula | C40H78N18O11 |
|---|---|
| Molecular Weight | 987.16100 |
| Exact Mass | 986.61000 |
| PSA | 518.21000 |
| LogP | 0.20500 |
| InChIKey | FDCBNCDCLDMQDU-UHFFFAOYSA-N |
| SMILES | CC(NC(=O)C(C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCCCN)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)NC(C(=O)NC(CO)C(N)=O)C(C)O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles3
More Articles| Minimum requirements for inhibition of smooth-muscle myosin light-chain kinase by synthetic peptides. Biochem. J. 257 , 73, (1989) Although the amino acid residues that are important for peptide substrates of myosin light-chain kinase have been reported, those that are important for peptide inhibitors of this enzyme have not prev... | |
| Smooth muscle myosin kinase requires residues on the COOH-terminal side of the phosphorylation site. Peptide inhibitors. J. Biol. Chem. 261 , 25, (1986) The COOH-terminal residue in peptide analogs of the phosphorylation site sequence in smooth muscle myosin light chains, Lys11-Lys12-Arg13-Ala-Ala-Arg16-Ala-Thr-Ser19 -(P)Asn20-Val21-Phe22-Ala23, were ... | |
| Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain. J. Biol. Chem. 262 , 11958-11963, (1987) A synthetic peptide modeled after the calmodulin (CaM)-binding domain of rabbit skeletal muscle myosin light chain kinase, Lys-Arg-Arg-Trp-Lys5-Lys-Asn-Phe-Ile-Ala10-Val-Ser-Ala-Ala-+ ++Asn15-Arg-Phe-... |
Synonyms
| MYOSIN KINASE INHIBITING PEPTIDE |
| Myosin Light Chain Kinase Fragment 11-19 amide |
| LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-AMIDE |
| LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2 |
| KKRAARATS-NH2 |
| myosin light chain kinase fragment 11-19 amide |
| MYOSIN LIGHT CHAIN KINASE (11-19) AMIDE |
