CAS 99200-09-6|Nebivolol
Introduction：Basic information about CAS 99200-09-6|Nebivolol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nebivolol | ||
|---|---|---|---|
| CAS Number | 99200-09-6 | Molecular Weight | 405.43500 |
| Density | 1.309 g/cm3 | Boiling Point | 600.5ºC at 760 mmHg |
| Molecular Formula | C22H25F2NO4 | Melting Point | 155-156°C(lit.) |
| MSDS | / | Flash Point | 316.9ºC |
Names
| Name | 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] |
|---|---|
| Synonym | More Synonyms |
Nebivolol BiologicalActivity
| Description | (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
| Target | IC50: 0.8 nM (β1-adrenergic receptor)[1] |
| In Vivo | Nebivolol (10 mg/kg; daily for 7 days) markedly improves endothelial dysfunction and increases P-VASP levels; prevents NOS III uncoupling; significantly inhibit NADPH oxidase in Angiotensin II-treated rats[3]. |
| References | [1]. do Vale GT, et al. Nebivolol Prevents Up-Regulation of Nox2/NADPH Oxidase and Lipoperoxidation in the Early Stages of Ethanol-Induced Cardiac Toxicity. Cardiovasc Toxicol. 2021 Mar;21(3):224-235. [2]. Cockcroft JR, et al. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J Pharmacol Exp Ther. 1995 Sep;274(3):1067-71. [3]. Oelze M, et al. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension. 2006 Oct;48(4):677-84. |
Chemical & Physical Properties
| Density | 1.309 g/cm3 |
|---|---|
| Boiling Point | 600.5ºC at 760 mmHg |
| Melting Point | 155-156°C(lit.) |
| Molecular Formula | C22H25F2NO4 |
| Molecular Weight | 405.43500 |
| Flash Point | 316.9ºC |
| Exact Mass | 405.17500 |
| PSA | 70.95000 |
| LogP | 2.75450 |
| Index of Refraction | 1.58 |
| InChIKey | KOHIRBRYDXPAMZ-UHFFFAOYSA-N |
| SMILES | OC(CNCC(O)C1CCc2cc(F)ccc2O1)C1CCc2cc(F)ccc2O1 |
| Storage condition | 20°C |
Synonyms
| Nebivolol |
| MFCD00865796 |
| (S,R,R,R)-NEBIVOLOL-D2,15N HYDROCHLORIDE |
| Nibivolol |
| rac-nebivolol |
| NEBIVOLOLHCL |
| NEBIVOLOL HYDROCHLORIDE |
| NEBIVOLOL-D4 |
