CAS 264622-53-9|MRS 1706

Introduction：Basic information about CAS 264622-53-9|MRS 1706, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. MRS 1706 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	MRS 1706
CAS Number	264622-53-9	Molecular Weight	503.55000
Density	/	Boiling Point	/
Molecular Formula	C₂₇H₂₉N₅O₅	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Synonym	More Synonyms

MRS 1706 BiologicalActivity

Description	MRS-1706 is a potent and selective A(2B) adenosine receptor antagonist with a Ki value of 1.39 nM.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adenosine ReceptorResearch Areas >>Inflammation/Immunology
Target	IC50: 1.39 nM (A(2B) human adenosine receptor)[1].
In Vitro	MRS-1706 is a selective adenosine A2B receptor inverse agonist with Ki values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively[1]. Pretreatment with ZM241385 (A2A-Ado receptor antagonist) alone or in combination with MRS-1706 (A2B-Ado receptor antagonist) results in a pure constriction upon adenosine[2].
References	[1]. Kim YC, et al. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J Med Chem. 2000 Mar 23;43(6):1165-72. [2]. Lai EY, et al. Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction. Kidney Int. 2006 Aug;70(4):690-8.

Chemical & Physical Properties

Molecular Formula	C₂₇H₂₉N₅O₅
Molecular Weight	503.55000
Exact Mass	503.21700
PSA	128.08000
LogP	3.66640
InChIKey	ZKUCFFYOQOJLGT-UHFFFAOYSA-N
SMILES	CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C(C)=O)cc4)cc3)nc2n(CCC)c1=O
Storage condition	2-8℃

Synonyms

MRS 1706

Tocris-1584

MRS-1706

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