Introduction：Basic information about CAS 93718-83-3|NSC 95397, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NSC 95397 |
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| CAS Number | 93718-83-3 | Molecular Weight | 310.39 |
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| Density | 1.46g/cm3 | Boiling Point | 499.2ºC at 760mmHg |
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| Molecular Formula | C14H14O4S2 | Melting Point | / |
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| MSDS | USA | Flash Point | 255.7ºC |
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Names
| Name | 2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione |
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| Synonym | More Synonyms |
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NSC 95397 BiologicalActivity
| Description | NSC 95397 is an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). NSC 95397 suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Phosphatase |
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| In Vitro | NSC 95397 (0, 10, and 20 µM; 24 hour) decreases the cell viability of three colon cancer cell lines SW480, SW620, and DLD-1 in a concentration-dependent manner[1]. NSC 95397(10 μM; 24 hour) upregulates p21 while downregulates CDK4 and CDK6 were d in all three colon cancer cell lines SW480, SW620, and DLD-1 cells[1]. NSC 95397 (10 μM; 24 hour) reduces the phosphorylation of retinoblastoma protein (Rb) on Ser795 and Ser807/811[1]. NSC 95397 (20 μM; 24 hours) significantly increases cleaved caspase-9, -3, -7 and PARP levels[1]. NSC 95397 (10 μM; 6 hours) enhances the phosphorylation of its downstream ERK1/2 at Thr202/Tyr 204[1]. Cell Viability Assay[1] Cell Line: Human colon cancer cell lines, SW480, SW620, and DLD-1 Concentration: 0, 10, and 20 µM Incubation Time: 24 hours Result: The IC50 values of NSC 95397 for the cell growth of SW480, SW620, and DLD-1 cells were 9.9, 14.1 and 18.6 μM, respectively. Western Blot Analysis[1] Cell Line: SW480, SW620, and DLD-1 cells Concentration: 10 μM Incubation Time: 24 hours Result: p21 was upregulated while CDK4 and CDK6 were downregulated. Rduced the phosphorylation of Rb on Ser795 and Ser807/811 |
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| References | [1]. Dubey NK, et al. NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway. Int J Mol Sci. 2018 May 31;19(6). pii: E1625. |
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Chemical & Physical Properties
| Density | 1.46g/cm3 |
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| Boiling Point | 499.2ºC at 760mmHg |
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| Molecular Formula | C14H14O4S2 |
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| Molecular Weight | 310.39 |
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| Flash Point | 255.7ºC |
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| Exact Mass | 310.03300 |
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| PSA | 125.20000 |
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| LogP | 1.72820 |
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| InChIKey | MAASHDQFQDDECQ-UHFFFAOYSA-N |
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| SMILES | O=C1C(SCCO)=C(SCCO)C(=O)c2ccccc21 |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2930909090 |
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Customs
| HS Code | 2930909090 |
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| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles1
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| Characterization of in vivo keratin 19 phosphorylation on tyrosine-391. PLoS ONE 5 , e13538, (2010) Keratin polypeptide 19 (K19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia. Although K19 is known to be phosphorylated on tyrosine residue(s), con... | |
Synonyms
| 2,3-bis(2-hydroxyethylsulfanyl)naphthalene-1,4-dione |
