CAS 23256-33-9|Dimaprit dihydrochloride
| Common Name | Dimaprit dihydrochloride | ||
|---|---|---|---|
| CAS Number | 23256-33-9 | Molecular Weight | 234.19000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C6H17Cl2N3S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Dimaprit dihydrochloride |
|---|---|
| Synonym | More Synonyms |
Dimaprit dihydrochloride BiologicalActivity
| Description | Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>EndocrinologySignaling Pathways >>Immunology/Inflammation >>NO SynthaseSignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
| Target | H2 Receptor nNOS:49 μM (IC50) |
| In Vitro | Dimaprit has less than 0.0001% the activity of histamine on H1-receptors[1]. Dimaprit (0.1 nM-100 μM) inhibits nNOS concentration dependently with an IC50 of 49±14 μM[2]. |
| In Vivo | Dimaprit stimulates gastric acid secretion in rats (1.25 μM/kg/min; rapid i.v. injection), cats (2-64 μM/h; i.v.) and dogs (1-100 nM/kg/min; i.v.)[1]. Dimaprit (0.01-1 μM/kg; i.v. at intervals of 5 min) causes dose-dependent falls in blood pressure in cats. Dimaprit (1-100 nM; intra-arterial injection) causes vasodilatation in the femoral vascular bed, and it (1 μM/kg; bolus or intravenous injection) has no effect on heart rate[1]. |
| References | [1]. Parsons ME, et, al. Dimaprit -(S-[3-(N,N-dimethylamino)prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7(1): 31-7. [2]. Paquay JB, et, al. Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br J Pharmacol. 1999 May; 127(2): 331-4. |
Chemical & Physical Properties
| Molecular Formula | C6H17Cl2N3S |
|---|---|
| Molecular Weight | 234.19000 |
| Exact Mass | 233.05200 |
| PSA | 78.41000 |
| LogP | 2.96880 |
| InChIKey | DFWCPLGXFMSUCW-UHFFFAOYSA-N |
| SMILES | CN(C)CCCSC(=N)N.Cl.Cl |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| HS Code | 2930909090 |
Preparation
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| S-(3-Dimethylaminopropyl)isothiourea dihydrobromide |
| Carbamimidothioic acid (3-(dimethylamino)propyl ester |
| 3-(dimethylamino)propyl carbamimidothioate,dihydrochloride |
