CAS 102146-07-6|DPCPX

Introduction：Basic information about CAS 102146-07-6|DPCPX, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. DPCPX BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles91
7. Synonyms

Common Name	DPCPX
CAS Number	102146-07-6	Molecular Weight	304.38700
Density	1.195g/cm3	Boiling Point	535.1ºC at 760mmHg
Molecular Formula	C₁₆H₂₄N₄O₂	Melting Point	178°C
MSDS	ChineseUSA	Flash Point	277.4ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	8-Cyclopentyl-1,3-dipropylxanthine
Synonym	More Synonyms

DPCPX BiologicalActivity

Description	DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes[1][2][3].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adenosine Receptor
Target	Ki: 0.46 nM (3H-CHA binding to A1 receptors in rat whole brain membranes); 340 nM (3H-NECA binding to A2 receptors in rat striatal membranes)[2].
In Vivo	DPCPX (PD 116948) ( 0.1, 0.3 and 1.0 mg/kg i.v. ) produces significant dose-related increases (P<0.05) in urine volume and in urinary sodium, potassium and chloride excretion[3].
References	[1]. S J Haleen, et al. PD 116,948, a Highly Selective A1 Adenosine Receptor Antagonist. Life Sci. 1987 Feb 9;40(6):555-61. [2]. R F Bruns, et al. Binding of the A1-selective Adenosine Antagonist 8-cyclopentyl-1,3-dipropylxanthine to Rat Brain Membranes. Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63. [3]. POSTER COMMUNICATIONS Part II. Br J Pharmacol. 1989 Jul; 97(Suppl): 496P–535P.

Chemical & Physical Properties

Density	1.195g/cm3
Boiling Point	535.1ºC at 760mmHg
Melting Point	178°C
Molecular Formula	C₁₆H₂₄N₄O₂
Molecular Weight	304.38700
Flash Point	277.4ºC
Exact Mass	304.19000
PSA	72.68000
LogP	2.36390
Appearance of Characters	solid \| white
Vapour Pressure	1.59E-11mmHg at 25°C
Index of Refraction	1.564
InChIKey	FFBDFADSZUINTG-UHFFFAOYSA-N
SMILES	CCCn1c(=O)c2[nH]c(C3CCCC3)nc2n(CCC)c1=O
Storage condition	Store at RT
Stability	Store tightly sealed at RT; Solutions at 4 deg C for several days
Water Solubility	DMSO: >10 mg/mL

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles91

Regulatory T cell-derived adenosine induces dendritic cell migration through the Epac-Rap1 pathway.

J. Immunol. 194(8) , 3735-44, (2015)

Dendritic cells (DC) are one target for immune suppression by regulatory T cells (Treg), because their interaction results in reduced T cell stimulatory capacity and secretion of inhibitory cytokines ...

Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase.

Eur. J. Pharm. Sci. 77 , 180-8, (2015)

In mammalian brain, monoacylglycerol lipase (MAGL) is the primary enzyme responsible for terminating signaling function of the endocannabinoid 2-arachidonoylglycerol (2-AG). Previous in vivo studies w...

Endothelial dysfunction impairs vascular neurotransmission in tail arteries.

Neurochem. Int. 80 , 7-13, (2015)

The present study intends to clarify if endothelium dysfunction impairs vascular sympathetic neurotransmission. Electrically-evoked tritium overflow (100 pulses/5 Hz) was evaluated in arteries (intact...

Synonyms

8-Cyclopentyl-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione

8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione

MFCD00055117

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