CAS 84468-24-6|HA-100

Introduction：Basic information about CAS 84468-24-6|HA-100, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. HA-100 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	HA-100
CAS Number	84468-24-6	Molecular Weight	277.34200
Density	1.332g/cm3	Boiling Point	497.4ºC at 760 mmHg
Molecular Formula	C₁₃H₁₅N₃O₂S	Melting Point	/
MSDS	/	Flash Point	254.6ºC

Names

Name	5-piperazin-1-ylsulfonylisoquinoline
Synonym	More Synonyms

HA-100 BiologicalActivity

Description	HA-100 is an inhibitor of cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), Protein kinase C (PKC) and MLC-kinase with IC50s of 4, 8, 12 and 240 μM, respectively.
Related Catalog	Signaling Pathways >>Cytoskeleton >>MyosinSignaling Pathways >>Protein Tyrosine Kinase/RTK >>PKASignaling Pathways >>Stem Cell/Wnt >>PKAResearch Areas >>Cancer
Target	PKC:12 μM (IC50) PKG:4 μM (IC50) PKA:8 μM (IC50) MLCK:240 μM (IC50)
References	[1]. Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

Chemical & Physical Properties

Density	1.332g/cm3
Boiling Point	497.4ºC at 760 mmHg
Molecular Formula	C₁₃H₁₅N₃O₂S
Molecular Weight	277.34200
Flash Point	254.6ºC
Exact Mass	277.08800
PSA	70.68000
LogP	2.17620
Index of Refraction	1.639
InChIKey	UPTYCYWTFGTCCG-UHFFFAOYSA-N
SMILES	O=S(=O)(c1cccc2cnccc12)N1CCNCC1
Storage condition	−20°C

Safety Information

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
WGK Germany	3
RTECS	TM0862600
HS Code	2935009090

Customs

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Synonyms

Tocris-0543

ha-100

MFCD01310980

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