CAS 69-25-0|Eledoisin acetate salt

Introduction：Basic information about CAS 69-25-0|Eledoisin acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Eledoisin acetate salt BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	Eledoisin acetate salt
CAS Number	69-25-0	Molecular Weight	1188.396
Density	1.3±0.1 g/cm3	Boiling Point	1618.1±65.0 °C at 760 mmHg
Molecular Formula	C₅₄H₈₅N₁₃O₁₅S	Melting Point	/
MSDS	/	Flash Point	932.4±34.3 °C

Names

Name	Eledoisin
Synonym	More Synonyms

Eledoisin acetate salt BiologicalActivity

Description	Eledoisin is a specific agonist of NK2 and NK3 receptors. Sequence: {Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>OthersPeptides
Target	NK2 and NK3 receptors[1].
In Vitro	Eledoisin increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively[1].
In Vivo	Eledoisin (0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice[2].
References	[1]. Lippe C, et al. Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin. Peptides. 2004 Nov;25(11):1971-5. [2]. Severini C, et al. The tachykinin peptide family. Pharmacol Rev. 2002 Jun;54(2):285-322.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	1618.1±65.0 °C at 760 mmHg
Molecular Formula	C₅₄H₈₅N₁₃O₁₅S
Molecular Weight	1188.396
Flash Point	932.4±34.3 °C
Exact Mass	1187.600830
PSA	463.25000
LogP	-1.36
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.569
InChIKey	AYLPVIWBPZMVSH-FCKMLYJASA-N
SMILES	CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C1CCCN1C(=O)C1CCC(=O)N1)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(N)=O
Storage condition	−20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JX8688000

CHEMICAL NAME :: Eledoisin

CAS REGISTRY NUMBER :: 69-25-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C54-H85-N13-O15-S

MOLECULAR WEIGHT :: 1188.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Cardiac - other changes Vascular - BP lowering not characterized in autonomic section

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 18,58,1962

Safety Information

WGK Germany	3
RTECS	JX8688000

Synonyms

5-Oxo-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-α-aspartyl-L-alanyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-L-methioninamide

PGLU-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2

ELEDOSIN

GLP-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2

PYR-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2

eledonepeptide

5-Oxo-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-aspartyl-L-alanyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-L-methioninamide

Eledone peptide

L-methioninamide, 5-oxo-L-prolyl-L-prolyl-L-seryl-L-lysyl-L-α-aspartyl-L-alanyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-

pEPSKDAFIGLM-NH2

FI 6225 TF/Ocoa

5-Oxo-L-Pro-L-Pro-L-Ser-L-Lys-L-Asp-L-Ala-L-Phe-L-Ile-Gly-L-Leu-L-Met-NH2

PYR-PSKDAFIGLM-NH2

eledoisin

Eledoisin Acetate

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