CAS 101932-71-2|Calyculin A
| Common Name | Calyculin A | ||
|---|---|---|---|
| CAS Number | 101932-71-2 | Molecular Weight | 1009.17000 |
| Density | 1.25g/cm3 | Boiling Point | / |
| Molecular Formula | C50H81N4O15P | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | Calyculin A from Discodermia calyx |
|---|---|
| Synonym | More Synonyms |
Calyculin A BiologicalActivity
| Description | Calyculin A is a potent and cell-permeable protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.5 to 1 nM. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>PhosphataseResearch Areas >>Cancer |
| References | [1]. Ishihara H, et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem Biophys Res Commun. 1989 Mar 31;159(3):871-7. |
Chemical & Physical Properties
| Density | 1.25g/cm3 |
|---|---|
| Molecular Formula | C50H81N4O15P |
| Molecular Weight | 1009.17000 |
| Exact Mass | 1008.54000 |
| PSA | 296.80000 |
| LogP | 5.07988 |
| Index of Refraction | 1.57 |
| InChIKey | FKAWLXNLHHIHLA-YCBIHMBMSA-N |
| SMILES | COCC(C(O)C(O)C(=O)NCCC(C)c1nc(C=CCC2OC3(CC(O)C2C)OC(C(CC(O)C(C)C(O)C(C)C=C(C)C(C)=CC=CC(C)=CC#N)OC)C(OP(=O)(O)O)C3(C)C)co1)N(C)C |
| Storage condition | 2-8℃ |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331-H315 |
| Precautionary Statements | P261-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic; |
| Risk Phrases | 23/24/25-38 |
| Safety Phrases | 36/37/39-45 |
| RIDADR | UN 3462 6.1/PG 3 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
Articles35
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| Detachment-induced autophagy in three-dimensional epithelial cell cultures. Meth. Enzymol. 452 , 423-39, (2009) Integrin-mediated cell adhesion to extracellular matrix (ECM) is critical for normal epithelial cell survival; cells deprived of ECM contact rapidly undergo apoptotic cell death, termed anoikis. Recen... | |
| Unique features of the okadaic acid activity class of tumor promoters. J. Cancer Res. Clin. Oncol. 125 , 150-155, (1999) Following the first report of tumor promotion by okadaic acid in 1988, we further identified additional tumor promoters of the okadaic acid activity class, such as calyculin A and microcystin-LR. Howe... |
Synonyms
| Calyculin A,N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-o |
| MFCD00133156 |
| Calyculin A |
