CAS 10083-24-6|Piceatannol

Introduction：Basic information about CAS 10083-24-6|Piceatannol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Piceatannol BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles92
7. Synonyms

Common Name	Piceatannol
CAS Number	10083-24-6	Molecular Weight	244.243
Density	1.5±0.1 g/cm3	Boiling Point	507.3±38.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₂O₄	Melting Point	223-227ºC
MSDS	ChineseUSA	Flash Point	252.2±21.4 °C

Names

Name	Piceatannol
Synonym	More Synonyms

Piceatannol BiologicalActivity

Description	Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]
Related Catalog	Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Protein Tyrosine Kinase/RTK >>SykResearch Areas >>CancerNatural Products >>Phenols
References	[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7. [2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.

Description

Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide. [1]

Related Catalog

Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Protein Tyrosine Kinase/RTK >>SykResearch Areas >>CancerNatural Products >>Phenols

References

[1]. Kazuhiro Ashikawa et al. Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation. J Immunol, 2002 Dec 1, 169(11):6490-7.

[2]. Wen-Pin Chen et al. Piceatannol, a derivative of resveratrol, moderately slows INa inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol.2009 Jun, 157(3), 381-391.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	507.3±38.0 °C at 760 mmHg
Melting Point	223-227ºC
Molecular Formula	C₁₄H₁₂O₄
Molecular Weight	244.243
Flash Point	252.2±21.4 °C
Exact Mass	244.073563
PSA	80.92000
LogP	2.69
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.801
InChIKey	CDRPUGZCRXZLFL-OWOJBTEDSA-N
SMILES	Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1
Storage condition	2-8°C
Water Solubility	H2O: 0.5 mg/mL

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2907299090

Customs

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Articles92

A unique mechanism of curcumin inhibition on F1 ATPase

Biochem. Biophys. Res. Commun. 452(4) , 940-4, (2014)

• Polyphenols lowered the rotation rate of F1 ATPase by increasing catalytic dwell. • Curcumin showed different inhibitory mechanism from other polyphenols. • γ subunit carboxyl terminus is not requir...

Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs.

J. Immunol. 194(4) , 1856-66, (2015)

During secondary immune responses, Ab-opsonized bacteria are efficiently taken up via FcRs by dendritic cells. We now demonstrate that this process induces cross-talk between FcRs and TLRs, which resu...

TH2 cells and their cytokines regulate formation and function of lymphatic vessels.

Nat. Commun. 6 , 6196, (2015)

Lymphatic vessels (LVs) are critical for immune surveillance and involved in the pathogenesis of diverse diseases. LV density is increased during inflammation; however, little is known about how the r...

Synonyms

3,3',4'5-Tetrahydroxystilbene

E-Piceatannol

1,2-Benzenediol, 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]-

3,3′,4,5′-Tetrahydroxy-trans-stilbene

3,3',4,5'-Tetrahydroxy-trans-stilbene

3,4,3',5'-Tetrahydroxy-trans-stilbene

4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]benzene-1,2-diol

3,5,3',4'-tetrahydroxystilbene

4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,2-benzenediol

Piceatannol

4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol

MFCD00221715

4-(2-(3,5-Dihydroxyphenyl)vinyl)-1,2-benzenediol

(E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

5-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]benzene-1,3-diol

trans-3,3',4,5'-tetrahydroxystilbene

3,3',4,5'-tetrahydroxystilbene

Piceatannol, (E)-

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