CAS 105637-50-1|ML-9
| Common Name | ML-9 | ||
|---|---|---|---|
| CAS Number | 105637-50-1 | Molecular Weight | 361.287 |
| Density | / | Boiling Point | 508.8ºC at 760mmHg |
| Molecular Formula | C15H18Cl2N2O2S | Melting Point | 196-200ºC |
| MSDS | USA | Flash Point | 261.5ºC |
Names
| Name | 1-(5-Chloronaphthalenesulfonyl)-1H-hexahydro-1,4-diazepine, Hydrochloride |
|---|---|
| Synonym | More Synonyms |
ML-9 BiologicalActivity
| Description | ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cytoskeleton >>Myosin |
| In Vitro | ML9 (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM significantly induces cell death[2]. ML9 (50 μM; 1-4 hours) significantly increases cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%[2]. Cell Viability Assay[1] Cell Line: Neonatal rat ventricular myocytes (NRVM) cells Concentration: 0, 10, 50 and 100 μM Incubation Time: 0, 1, 4, 8 and 24 hours Result: Decreased cell viability at 50-100 μM concentration. Apoptosis Analysis[1] Cell Line: Neonatal rat ventricular myocytes (NRVM) cells Concentration: 50 μM Incubation Time: 1, 4 and 8 hours Result: Induced cardiomyocyte death through necrosis and apoptosis. |
| References | [1]. Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23;486(3):325-33. [2]. Shaikh S, et al. The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.Toxicol In Vitro. 2018 Apr;48:121-127. [3]. Kondratskyi A1, et al.Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.Cell Death Dis. 2014 Apr 24;5:e1193. |
Chemical & Physical Properties
| Boiling Point | 508.8ºC at 760mmHg |
|---|---|
| Melting Point | 196-200ºC |
| Molecular Formula | C15H18Cl2N2O2S |
| Molecular Weight | 361.287 |
| Flash Point | 261.5ºC |
| Exact Mass | 360.046600 |
| PSA | 57.79000 |
| LogP | 4.62670 |
| Vapour Pressure | 1.79E-10mmHg at 25°C |
| InChIKey | ZNRYCIVTNLZOGI-UHFFFAOYSA-N |
| SMILES | Cl.O=S(=O)(c1cccc2c(Cl)cccc12)N1CCCNCC1 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles31
More Articles| Modulation of macrophage phenotype by cell shape. Proc. Natl. Acad. Sci. U. S. A. 110(43) , 17253-8, (2013) Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Although much is known about how soluble factors influence macrophage polarization, relati... | |
| Calcium-Dependent Isoforms of Protein Kinase C Mediate Posttetanic Potentiation at the Calyx of Held Neuron 70(5) , 1005-19, (2011) High-frequency stimulation leads to a transient increase in the amplitude of evoked synaptic transmission that is known as posttetanic potentiation (PTP). Here we examine the roles of the calcium-depe... | |
| Linalyl acetate as a major ingredient of lavender essential oil relaxes the rabbit vascular smooth muscle through dephosphorylation of myosin light chain. J. Cardiovasc. Pharmacol. 48(1) , 850-6, (2006) In a preliminary experiment, we found that lavender essential oil relaxes vascular smooth muscle. Thus, the present experiments were designed to investigate the relaxation mechanism of linalyl acetate... |
Synonyms
| 1H-1,4-Diazepine, 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-, hydrochloride (1:1) |
| 1-[(5-Chloro-1-naphthyl)sulfonyl]-1,4-diazepane hydrochloride (1:1) |
| 1-(5-chloronaphthalen-1-yl)sulfonyl-1,4-diazepane,hydrochloride |
| MFCD00065525 |
