Introduction：Basic information about CAS 118414-82-7|MK886, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MK886 |
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| CAS Number | 118414-82-7 | Molecular Weight | 472.08 |
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| Density | 1.14g/cm3 | Boiling Point | 623.4ºC at 760mmHg |
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| Molecular Formula | C27H34ClNO2S | Melting Point | 295-297ºC |
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| MSDS | / | Flash Point | 330.8ºC |
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Names
| Name | 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid |
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| Synonym | More Synonyms |
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MK886 BiologicalActivity
| Description | MK886 is a 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM). |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>FLAPResearch Areas >>Cancer |
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| References | [1]. [1] Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15. [2]. [2] Gillard J et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67(5):456-64. [3]. [3] Dixon RA et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature, 1990 Jan 18, 343(6255):282-4.http://www.ncbi.nlm.nih.gov/pubmed/2300173 |
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Chemical & Physical Properties
| Density | 1.14g/cm3 |
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| Boiling Point | 623.4ºC at 760mmHg |
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| Melting Point | 295-297ºC |
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| Molecular Formula | C27H34ClNO2S |
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| Molecular Weight | 472.08 |
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| Flash Point | 330.8ºC |
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| PSA | 70.36000 |
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| LogP | 6.67560 |
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| Vapour Pressure | 2.11E-16mmHg at 25°C |
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| Index of Refraction | 1.58 |
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| InChIKey | QAOAOVKBIIKRNL-UHFFFAOYSA-N |
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| SMILES | CC(C)c1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1 |
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| Storage condition | -20℃ |
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Safety Information
Synonyms
| Sodium 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropanoate |
| 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-, sodium salt (1:1) |
| Pizotifenum |
| Pizotifene |
| SIN-1 chloride |
| PIZOTYLINE |
| Sandomygran |
| BC-105 |
| Pizotifeno |
| Litec |
| Pizotifen |
| Sandomigran |
| Polomigran |
| Sodium 3-{1-(4-chlorobenzyl)-5-isopropyl-3-[(2-methyl-2-propanyl)sulfanyl]-1H-indol-2-yl}-2,2-dimethylpropanoate |
| MK-886 |
