CAS 304-52-9|α-Methyl-5-hydroxytryptamine maleate

Introduction：Basic information about CAS 304-52-9|α-Methyl-5-hydroxytryptamine maleate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. α-Methyl-5-hydroxytryptamine maleate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	α-Methyl-5-hydroxytryptamine maleate
CAS Number	304-52-9	Molecular Weight	306.31400
Density	/	Boiling Point	411.7ºC at 760 mmHg
Molecular Formula	C₁₅H₁₈N₂O₅	Melting Point	/
MSDS	/	Flash Point	202.8ºC

Names

Name	α-Methyl-5-hydroxytryptamine maleate
Synonym	More Synonyms

α-Methyl-5-hydroxytryptamine maleate BiologicalActivity

Description	α-Methylserotonin is a potent and selective agonist of 5-HT2 receptor.α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan.α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis[1][2][3].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor
References	[1]. Dobbins DE. Receptor mechanisms of serotonin-induced prenodal lymphatic constriction in the canine forelimb. Am J Physiol. 1998 Feb;274(2):H650-4. [2]. Brumley MR, et al. The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behav Neurosci. 2005 Jun;119(3):821-33. [3]. Edwards E, et al. (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane(DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 1992 Jul;31(7):615-21.

Description

α-Methylserotonin is a potent and selective agonist of 5-HT2 receptor.α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan.α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis[1][2][3].

Related Catalog

Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor

References

[1]. Dobbins DE. Receptor mechanisms of serotonin-induced prenodal lymphatic constriction in the canine forelimb. Am J Physiol. 1998 Feb;274(2):H650-4.

[2]. Brumley MR, et al. The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behav Neurosci. 2005 Jun;119(3):821-33.

[3]. Edwards E, et al. (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane(DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 1992 Jul;31(7):615-21.

Chemical & Physical Properties

Boiling Point	411.7ºC at 760 mmHg
Molecular Formula	C₁₅H₁₈N₂O₅
Molecular Weight	306.31400
Flash Point	202.8ºC
Exact Mass	306.12200
PSA	136.64000
LogP	2.17530
InChIKey	LYPCGXKCQDYTFV-UHFFFAOYSA-N
SMILES	CC(N)Cc1c[nH]c2ccc(O)cc12

Safety Information

Safety Phrases	22-24/25
WGK Germany	3

Synonyms

MFCD00082468

4a-methyl-5-hydroxytryptamine

a-Methyl-5-hydroxytryptaminemaleate

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