CAS 52809-07-1|Quisqualic acid
| Common Name | Quisqualic acid | ||
|---|---|---|---|
| CAS Number | 52809-07-1 | Molecular Weight | 189.126 |
| Density | 2.0±0.1 g/cm3 | Boiling Point | 405.9±55.0 °C at 760 mmHg |
| Molecular Formula | C5H7N3O5 | Melting Point | 185-187ºC dec. |
| MSDS | ChineseUSA | Flash Point | 199.3±31.5 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (+)-Quisqualic Acid |
|---|---|
| Synonym | More Synonyms |
Quisqualic acid BiologicalActivity
| Description | Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis chinensis[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRSignaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
| Target | mGluR1R:45 nM (EC50) mGluR1R:10 nM (Ki) mGluR2R:108 μM (IC50) mGluR2R:113 μM (Ki) mGluR4R:593 μM (IC50) mGluR4R:112 μM (Ki) |
| In Vitro | Quisqualic acid is an agonist of AMPA and metabotropic glutamate receptors. Quisqualic acid activates mGluR2R (EC50=108 μM; Ki=113 μM) and mGluR4R (EC50=593 μM; Ki=112 μM)[1]. |
| References | [1]. Hugues-Olivier Bertrand, et al. Common and Selective Molecular Determinants Involved in Metabotopic Glutamate Receptor Agonist Activity. J Med Chem. 2002 Jul 18;45(15):3171-83. [2]. H Bräuner-Osborne, et al. Ligands for Glutamate Receptors: Design and Therapeutic Prospects. J Med Chem. 2000 Jul 13;43(14):2609-45. |
Chemical & Physical Properties
| Density | 2.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 405.9±55.0 °C at 760 mmHg |
| Melting Point | 185-187ºC dec. |
| Molecular Formula | C5H7N3O5 |
| Molecular Weight | 189.126 |
| Flash Point | 199.3±31.5 °C |
| Exact Mass | 189.038574 |
| PSA | 131.32000 |
| LogP | -1.85 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.726 |
| InChIKey | ASNFTDCKZKHJSW-REOHCLBHSA-N |
| SMILES | NC(Cn1oc(=O)[nH]c1=O)C(=O)O |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | R20/21/22 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| L-Alanine, 3-(3-hydroxy-5-oxo-1,2,4-oxadiazol-2(5H)-yl)- |
| L-Quisqualic acid |
| L-Alanine, 3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)- |
| 1,2,4-Oxadiazolidine-2-propanoic acid, α-amino-3,5-dioxo-, (S)- |
| MFCD00069337 |
| 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine |
| b-(3,5-Dioxo-1,2,4-oxodiazolidin-2-yl)-L-alanine |
| L-(+)-a-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic Acid |
| (L)-(+)-a-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid |
| Quisqualic acid |
| 3-(3-Hydroxy-5-oxo-1,2,4-oxadiazol-2(5H)-yl)-L-alanine |
| β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine |
| L-Quisqualic acid,(L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoicacid |
| (S)-a-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic Acid |
