CAS 120934-96-5|FPL64176
| Common Name | FPL64176 | ||
|---|---|---|---|
| CAS Number | 120934-96-5 | Molecular Weight | 347.40700 |
| Density | 1.174g/cm3 | Boiling Point | 547.8ºC at 760mmHg |
| Molecular Formula | C22H21NO3 | Melting Point | 144 - 145 °C |
| MSDS | ChineseUSA | Flash Point | 285.1ºC |
Names
| Name | fpl 64176 |
|---|---|
| Synonym | More Synonyms |
FPL64176 BiologicalActivity
| Description | FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca2+ channels with an EC50 value of 16 nM[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease |
| References | [1]. Zheng W, Rampe D, Triggle DJ. Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol Pharmacol. 1991 Nov;40(5):734-41. [2]. Baxter AJ, Dixon J, Ince F, Manners CN, Teague SJ. Discovery and synthesis of methyl 2,5-dimethyl-4-[2- (phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J Med Chem. |
Chemical & Physical Properties
| Density | 1.174g/cm3 |
|---|---|
| Boiling Point | 547.8ºC at 760mmHg |
| Melting Point | 144 - 145 °C |
| Molecular Formula | C22H21NO3 |
| Molecular Weight | 347.40700 |
| Flash Point | 285.1ºC |
| Exact Mass | 347.15200 |
| PSA | 59.16000 |
| LogP | 4.23990 |
| Vapour Pressure | 4.72E-12mmHg at 25°C |
| Index of Refraction | 1.6 |
| InChIKey | MDMWHKZANMNXTF-UHFFFAOYSA-N |
| SMILES | COC(=O)c1c(C)[nH]c(C)c1C(=O)c1ccccc1Cc1ccccc1 |
| Storage condition | 2-8°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles30
More Articles| Metformin as adjunct antituberculosis therapy. Sci. Transl. Med. 6(263) , 263ra159, (2014) The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential new approach to TB therapy is to augment protective host immune responses. We report that the antidiabetic d... | |
| A pharmacological model for calcium overload-induced tachycardia in isolated rat left atria. Eur. J. Pharmacol. 576(1-3) , 122-31, (2007) Few experimental models produce spontaneous tachycardia in normal left atria to allow the study of the cellular mechanisms underlying this contributor to atrial fibrillation. We reported 2-aminoethoxy... | |
| Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels. Brain Res. 1276 , 159-70, (2009) Estrogen-mediated neuroprotection is observed in neurodegenerative disease and neurotrauma models; however, determining a mechanism for these effects has been difficult. We propose that estrogen may l... |
Synonyms
| 2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxlic acid methyl ester |
| MFCD00274043 |
| methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate |
