CAS 22919-26-2|Disodium 4-methyl-2-oxo-2H-chromen-7-yl phosphate
| Common Name | Disodium 4-methyl-2-oxo-2H-chromen-7-yl phosphate | ||
|---|---|---|---|
| CAS Number | 22919-26-2 | Molecular Weight | 300.112 |
| Density | / | Boiling Point | 511.4ºC at 760 mmHg |
| Molecular Formula | C10H7Na2O6P | Melting Point | / |
| MSDS | USA | Flash Point | 263.1ºC |
Names
| Name | disodium,(4-methyl-2-oxochromen-7-yl) phosphate |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | 4-Methylumbelliferyl phosphate (4-MUP) disodium, an anionic organophosphate, is a acid and alkaline phosphatase fluorogenic substrate. 4-Methylumbelliferyl phosphate disodium is also a nerve agent simulant[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>PhosphataseResearch Areas >>Others |
| In Vitro | Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). Serum acid phosphatase assay[1]: 1. Preparation a 100 μL solution containing the following agents: 5.0 μL of serum enzyme, 50 μL of 4-Methylumbelliferyl phosphate (5.0 mM), and 10 μL of 1.0 M buffer at pH 6.0. 2. Add the following agents (with the final concentration) 20 mM Sodium Tartrate (HY-128476), 15 mM Sodium Fluoride (HY-B1766), 3000 mM 2-Mercaptoethanol, 4 mM 1, 10-Phenanthroline (HY-W004544), 6 mM 8-Quinolinol (HY-B1005), 6 mM 8-Hydroxy-5quinolinesulfonic acid, 45 mM EDTA (HY-Y0682) and 6 mM EGTA (HY-D0861). 3. Incubate reaction mixtures for 15 min at 37℃ and terminated by the addition of 2.9 mL of 0.1 M ammonium hydroxide/glycine buffer, pH 10.5. 4. Mix samples thoroughly and determine fluorescence by a fluorometer. |
| References | [1]. Chambers JP, et al. Determination of serum acid phosphatase in Gaucher's disease using 4-methylumbelliferyl phosphate. Clin Chim Acta. 1977 Oct 1;80(1):67-77. [2]. Watanabe F, et al. The analysis of alkaline phosphatase isoenzyme using 4-methylumbelliferyl phosphate as substrate on a cellulose acetate membrane. Clin Chim Acta. 1979 Feb 1;91(3):273-6. [3]. Hao Chen, et al. Autonomic Molecular Transport for Ultrasensitive Surface-Enhanced Infrared Absorption Spectroscopy. ACS Appl. Polym. Mater. 2020, 2, 9, 3929-3935 |
Chemical & Physical Properties
| Boiling Point | 511.4ºC at 760 mmHg |
|---|---|
| Molecular Formula | C10H7Na2O6P |
| Molecular Weight | 300.112 |
| Flash Point | 263.1ºC |
| Exact Mass | 299.977570 |
| PSA | 112.44000 |
| LogP | 2.44930 |
| Vapour Pressure | 2.79E-11mmHg at 25°C |
| InChIKey | WUUDJQVNZPEPKN-UHFFFAOYSA-L |
| SMILES | Cc1cc(=O)oc2cc(OP(=O)([O-])[O-])ccc12.[Na+].[Na+] |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Risk Phrases | 22-24/25 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932209090 |
Customs
| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Sodium 4-methyl-2-oxo-2H-chromen-7-yl phosphate |
| 4-Methylumbelliferyl phosphate sodium salt |
| 4-MUP,Disodium 4-methylumbelliferyl phosphate |
| EINECS 245-325-0 |
| Disodium 4-methyl-2-oxo-2H-chromen-7-yl phosphate |
| 2H-1-Benzopyran-2-one, 4-methyl-7-(phosphonooxy)-, sodium salt (1:2) |
| 4-Methylumbelliferylphosphate disodium salt trihydrate |
| 4-MUP |
| 4-Methylumbelliferyl phosphate,disodium salt |
| MFCD00037614 |
| Disodium 4-methylumbelliferyl phosphate |
