CAS 93265-81-7|Ropidoxuridine

Introduction：Basic information about CAS 93265-81-7|Ropidoxuridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Ropidoxuridine BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Ropidoxuridine
CAS Number	93265-81-7	Molecular Weight	338.09900
Density	2.22g/cm3	Boiling Point	478.6ºC at 760mmHg
Molecular Formula	C₉H₁₁IN₂O₄	Melting Point	/
MSDS	/	Flash Point	243.3ºC

Names

Name	1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one
Synonym	More Synonyms

Ropidoxuridine BiologicalActivity

Description	Ropidoxuridine (IPdR) is a novel orally available, halogenated thymidine analog and is a potential radiosensitizer for use in human tumors.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Cancer
In Vitro	Ropidoxuridine is an orally bioavailable pro-drug of IUdR (5-iodo-2'-deoxyuridine). Ropidoxuridine demonstrates strong synergy effects with Alisertib at clinically relevant concentrations[1].
In Vivo	In an orthotopic tumor model, Ropidoxuridine (750 mg/kg/day) and Alisertib (30 mg/kg/day) demonstrate strong synergy effects[1].
References	[1]. Rampurwala MM, et al. Ropidoxuridine (IPdR) potentiates alisertib (MLN8237) activity in triple-negative breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-13-16.

Chemical & Physical Properties

Density	2.22g/cm3
Boiling Point	478.6ºC at 760mmHg
Molecular Formula	C₉H₁₁IN₂O₄
Molecular Weight	338.09900
Flash Point	243.3ºC
Exact Mass	337.97600
PSA	84.58000
Index of Refraction	1.759
InChIKey	XIJXHOVKJAXCGJ-XLPZGREQSA-N
SMILES	O=c1ncc(I)cn1C1CC(O)C(CO)O1

Synonyms

5-Iodo-2-pyrimidinone-2'-deoxyribose

Ropidoxuridine (INN/USAN)

IPdR

Ropidoxuridine

UNII-3HX21A3SQF

Ropidoxuridine [USAN:INN]

5-Iodo-2-pyrimidinone 2' deoxyribonucleoside

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