Introduction：Basic information about CAS 3785-24-8|Nepodin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nepodin |
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| CAS Number | 3785-24-8 | Molecular Weight | 216.233 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 413.2±40.0 °C at 760 mmHg |
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| Molecular Formula | C13H12O3 | Melting Point | 165-166℃ (methanol ) |
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| MSDS | / | Flash Point | 217.8±23.8 °C |
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Names
| Name | 1-(1,8-dihydroxy-3-methylnaphthalen-2-yl)ethanone |
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| Synonym | More Synonyms |
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Nepodin BiologicalActivity
| Description | Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>AMPKResearch Areas >>InfectionSignaling Pathways >>PI3K/Akt/mTOR >>AMPK |
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| In Vitro | Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1]. |
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| In Vivo | Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2]. Animal Model: C57BL/KsJ-db/db mice[2] Dosage: 2 mg/kg; 10 mg/kg Administration: Orally administration; 2-10 mg/kg; 4 weeks Result: Had antihyperglycemic potential and improved insulin resistance. |
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| References | [1]. Lee KH, et al. Antimalarial activity of nepodin isolated from Rumex crispus. Arch Pharm Res. 2013 Apr;36(4):430-5. [2]. Ha BG, et al. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug;40(4):436-47. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 413.2±40.0 °C at 760 mmHg |
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| Melting Point | 165-166℃ (methanol ) |
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| Molecular Formula | C13H12O3 |
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| Molecular Weight | 216.233 |
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| Flash Point | 217.8±23.8 °C |
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| Exact Mass | 216.078644 |
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| PSA | 57.53000 |
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| LogP | 2.87 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.668 |
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| InChIKey | DMLHPCALHMPJHS-UHFFFAOYSA-N |
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| SMILES | CC(=O)c1c(C)cc2cccc(O)c2c1O |
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Safety Information
Customs
| HS Code | 2914400090 |
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| Summary | 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| Ethanone, 1-(1,8-dihydroxy-3-methyl-2-naphthalenyl)- |
| Dianellidin |
| dianellidine |
| 1,8-dihydroxy-2-acetyl-3-methylnaphthalene |
| 1-(1,8-Dihydroxy-3-methyl-2-naphthyl)ethanone |
| 1-(1,8-Dihydroxy-3-methyl-2-naphthalenyl)ethanone |
| Musizin |
| 2-acetyl-1,8-dihydroxy-3-methylnaphthalene |
| Nepodin |
