Introduction：Basic information about CAS 10212-20-1|2'-Deoxy-2'-fluorocytidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2'-Deoxy-2'-fluorocytidine |
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| CAS Number | 10212-20-1 | Molecular Weight | 245.208 |
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| Density | 1.8±0.1 g/cm3 | Boiling Point | 500.1±60.0 °C at 760 mmHg |
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| Molecular Formula | C9H12FN3O4 | Melting Point | 167ºC |
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| MSDS | / | Flash Point | 256.2±32.9 °C |
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Names
| Name | 2'-Deoxy-2'-fluorocytidine |
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| Synonym | More Synonyms |
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2'-Deoxy-2'-fluorocytidine BiologicalActivity
| Description | 2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication[1]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection |
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| In Vitro | 2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells[1]. |
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| References | [1]. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99. |
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Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
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| Boiling Point | 500.1±60.0 °C at 760 mmHg |
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| Melting Point | 167ºC |
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| Molecular Formula | C9H12FN3O4 |
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| Molecular Weight | 245.208 |
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| Flash Point | 256.2±32.9 °C |
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| Exact Mass | 245.081177 |
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| PSA | 110.60000 |
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| LogP | -1.26 |
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| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
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| Index of Refraction | 1.697 |
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| InChIKey | NVZFZMCNALTPBY-XVFCMESISA-N |
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| SMILES | Nc1ccn(C2OC(CO)C(O)C2F)c(=O)n1 |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 26-36 |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2'-Deoxy-2'-fluorocytidine |
| 2'-FdC |
| MFCD00057445 |
| 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| 2'-Deoxy-2'-fluoro-D-cytidine |
| 2'-FLUORO-D-CYTIDINE |
| 2'-FC |
| Cytidine, 2'-deoxy-2'-fluoro- |
| 2`-Deoxy-2`-fluoro Cytidine |
| RO-8013 |
| 2′-Fluoro-2′-deoxycytidine |
| 2'-Fluoro-2'-deoxycytidine |
