Introduction：Basic information about CAS 666-99-9|agaric acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | agaric acid |
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| CAS Number | 666-99-9 | Molecular Weight | 416.54900 |
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| Density | 1.115g/cm3 | Boiling Point | 509.3ºC at 760 mmHg |
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| Molecular Formula | C22H40O7 | Melting Point | 142° (dec) |
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| MSDS | ChineseUSA | Flash Point | 275.9ºC |
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Names
| Name | 2-hydroxynonadecane-1,2,3-tricarboxylic acid |
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| Synonym | More Synonyms |
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agaric acid BiologicalActivity
| Description | Agaric acid (Agaricinic Acid) is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism[1]. |
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| References | [1]. García N, et al. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity. Mitochondrion. 2005 Aug;5(4):272-81. |
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Chemical & Physical Properties
| Density | 1.115g/cm3 |
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| Boiling Point | 509.3ºC at 760 mmHg |
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| Melting Point | 142° (dec) |
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| Molecular Formula | C22H40O7 |
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| Molecular Weight | 416.54900 |
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| Flash Point | 275.9ºC |
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| Exact Mass | 416.27700 |
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| PSA | 132.13000 |
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| LogP | 4.84900 |
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| Index of Refraction | 1.501 |
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| InChIKey | HZLCGUXUOFWCCN-UHFFFAOYSA-N |
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| SMILES | CCCCCCCCCCCCCCCCC(C(=O)O)C(O)(CC(=O)O)C(=O)O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- RA5365000
- CHEMICAL NAME :
- 1,2,3-Nonadecanetricarboxylic acid, 2-hydroxy-
- CAS REGISTRY NUMBER :
- 666-99-9
- BEILSTEIN REFERENCE NO. :
- 1729981
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C22-H40-O7
- MOLECULAR WEIGHT :
- 416.62
- WISWESSER LINE NOTATION :
- QVY16&XQVQ1VQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
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Safety Information
| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | RA5365000 |
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Articles11
More Articles
| Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity. Mitochondrion 5 , 272-281, (2005) The effect of agaric acid as inducer of mitochondrial permeability transition was studied. It was found that: (i) agaric acid (AA) promoted efflux of accumulated Ca2+, collapse of transmembrane potent... | |
| The mechanisms of fatty acid-induced proton permeability of the inner mitochondrial membrane. J. Bioenerg. Biomembr. 31 , 447-455, (1999) Nonesterified long-chain fatty acids have long been known as uncouplers of oxidative phosphorylation. They are efficient protonophores in the inner mitochondrial membrane but not so in artificial phos... | |
| The effect of N-ethylmaleimide on permeability transition as induced by carboxyatractyloside, agaric acid, and oleate. Cell Biochem. Biophys. 51 , 81-87, (2008) In this work, we studied the effect of N-ethylmaleimide on permeability transition. The findings indicate that the amine inhibited the effects of carboxyatractyloside and agaric acid. It is known that... | |
Synonyms
| Laricic acid |
| n-Hexadecylcitric acid |
| EINECS 211-566-5 |
| Agaricinic acid |
| (2S,3S)-2-Hydroxy-nonadecan-1,2,3-tricarbonsaeure |
| Lr-2-Hydroxy-nonadecan-1,2rF,3cF-tricarbonsaeure |
| Agaric acid |
| Agaricinsaeure |
| MFCD00002665 |
| Agaricin |
| (2S,3S)-2-Hydroxy-nonadecan-1,2,3-tricarbonsaeure (Agaricinsaeure) |
| Agaricic acid |
| (2S,3S)-2-hydroxy-nonadecane-1,2,3-tricarboxylic acid |
