Introduction：Basic information about CAS 30918-54-8|Polyinosinic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Polyinosinic acid |
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| CAS Number | 30918-54-8 | Molecular Weight | 348.206 |
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| Density | 2.4±0.1 g/cm3 | Boiling Point | 905.4±75.0 °C at 760 mmHg |
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| Molecular Formula | C10H13N4O8P | Melting Point | / |
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| MSDS | / | Flash Point | 501.4±37.1 °C |
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Names
| Name | 5'-Inosinic acid polymers |
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| Synonym | More Synonyms |
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Polyinosinic acid BiologicalActivity
| Description | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation[1]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Toll-like Receptor (TLR)Research Areas >>Inflammation/Immunology |
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| In Vitro | Polyinosinic acid (50 µg/mL；24 h) 诱导 BALB/c B 细胞中 CD86、CD40 和 MHC II 的表达，BALB/c BMDC 细胞中 CD86 和 CD40 的表达[1]。 Polyinosinic acid (1、5 和 25 µg/mL；48 h) 以剂量依赖性方式加强了 BALB/c B 细胞对 [3H] 胸苷的摄取[1]。 Polyinosinic acid (50 µg/mL；20 h) 诱导 BALB/c BMDC 细胞和巨噬细胞分泌 TNFα 和 IL-12，BALB/c B 细胞、BMDC 细胞分泌 IFN。Polyinosinic acid 增加了 C57Bl/6、MyD88 敲除和 TLR4 敲除小鼠 B 细胞中 MHC II、CD86 的表达[1]。 Polyinosinic acid (50 µg/mL；48 h) 加强了 C57Bl/6、MyD88 敲除和 TLR4 敲除小鼠 B 细胞对胸苷的摄取[1]。 Polyinosinic acid (25 µg/mL 和 50 µg/mL；24 h) 以剂量依赖性方式诱导 BEAS-2B 细胞分泌 IP-10[1]。 Polyinosinic acid (50 µg/mL；24 h 或 48 h) 通过 TRIF 调节 TRIF+/+ 和 TRIF-/- 小鼠 B 细胞中 CD86 的表达及胸苷的摄取[1]。 Polyinosinic acid (10、20 或 50 µg/mL；20 h) 增加了 TLR3+/+ 来源的 BMDC 细胞分泌 IFN 和 IFNα，但不影响 TLR3-/- 来源的 BMDC 细胞[1]。 |
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| References | [1]. Marshall-Clarke S, et al. Polyinosinic acid is a ligand for toll-like receptor 3. J Biol Chem. 2007 Aug 24;282(34):24759-66. |
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Chemical & Physical Properties
| Density | 2.4±0.1 g/cm3 |
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| Boiling Point | 905.4±75.0 °C at 760 mmHg |
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| Molecular Formula | C10H13N4O8P |
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| Molecular Weight | 348.206 |
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| Flash Point | 501.4±37.1 °C |
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| Exact Mass | 348.047089 |
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| PSA | 189.83000 |
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| LogP | -2.65 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.918 |
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| InChIKey | GRSZFWQUAKGDAV-UHFFFAOYSA-N |
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| SMILES | O=c1[nH]cnc2c1ncn2C1OC(COP(=O)(O)O)C(O)C1O |
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| Storage condition | −20°C |
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Safety Information
Synonyms
| (1S)-1,4-Anhydro-1-(6-oxo-6,7-dihydro-1H-purin-8-yl)-5-O-phosphono-D-ribitol |
| Polyinosinic acid (Poly I) |
| (1S)-1,4-Anhydro-1-(6-oxo-6,9-dihydro-3H-purin-8-yl)-5-O-phosphono-D-ribitol |
| Polyinosinicacid |
| POLY[I] POTASSIUM SALT |
| POLY RL POTASSIUM SALT |
| D-Ribitol, 1,4-anhydro-1-C-(6,9-dihydro-6-oxo-3H-purin-8-yl)-, 5-(dihydrogen phosphate), (1S)- |
| Polyinosinic acid |
| Poly(rI) |
| Poly(IMP) |
| polyinosinicacidpot.salt |
