CAS 271247-12-2|(2,3,3,4,5,5,5,5',5',5'-2H10)Leucine

Introduction：Basic information about CAS 271247-12-2|(2,3,3,4,5,5,5,5',5',5'-2H10)Leucine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (2,3,3,4,5,5,5,5',5',5'-2H10)Leucine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(2,3,3,4,5,5,5,5',5',5'-2H10)Leucine
CAS Number	271247-12-2	Molecular Weight	141.23
Density	1.0±0.1 g/cm3	Boiling Point	225.8±23.0 °C at 760 mmHg
Molecular Formula	C₆H₃D₁₀NO₂	Melting Point	>300ºC(lit.)
MSDS	/	Flash Point	90.3±22.6 °C

Names

Name	d-leucine-d10
Synonym	More Synonyms

(2,3,3,4,5,5,5,5',5',5'-2H10)Leucine BiologicalActivity

Description	D-Leucine-d10 is the deuterium labeled D-Leucine. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193

Description

D-Leucine-d10 is the deuterium labeled D-Leucine. D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	225.8±23.0 °C at 760 mmHg
Melting Point	>300ºC(lit.)
Molecular Formula	C₆H₃D₁₀NO₂
Molecular Weight	141.23
Flash Point	90.3±22.6 °C
Exact Mass	141.157394
PSA	63.32000
LogP	0.73
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.463
InChIKey	ROHFNLRQFUQHCH-AWDMERPQSA-N
SMILES	CC(C)CC(N)C(=O)O

Safety Information

WGK Germany	3

Synonyms

Leucine-2,3,3,4,5,5,5,5',5',5'-d

(2,3,3,4,5,5,5,5',5',5'-H)Leucine

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