CAS 59864-04-9|Exisulind

Introduction：Basic information about CAS 59864-04-9|Exisulind, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Exisulind BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles32
6. Synonyms

Common Name	Exisulind
CAS Number	59864-04-9	Molecular Weight	372.41
Density	1.4±0.1 g/cm3	Boiling Point	601.9±55.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₇FO₄S	Melting Point	/
MSDS	USA	Flash Point	317.8±31.5 °C

Names

Name	Sulindac sulfone
Synonym	More Synonyms

Exisulind BiologicalActivity

Description	Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac[1]. Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications[2].
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Aldose ReductaseResearch Areas >>Metabolic Disease
References	[1]. Kitamura S, Tatsumi K. In vitro metabolism of sulindac and sulindac sulfide: enzymatic formation of sulfoxide and sulfone. Jpn J Pharmacol. 1982 Oct;32(5):833-8. [2]. Zheng X, et al. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase. FEBS Lett. 2012 Jan 2;586(1):55-9.

Description

Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac[1]. Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications[2].

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>Aldose ReductaseResearch Areas >>Metabolic Disease

References

[1]. Kitamura S, Tatsumi K. In vitro metabolism of sulindac and sulindac sulfide: enzymatic formation of sulfoxide and sulfone. Jpn J Pharmacol. 1982 Oct;32(5):833-8.

[2]. Zheng X, et al. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase. FEBS Lett. 2012 Jan 2;586(1):55-9.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	601.9±55.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₇FO₄S
Molecular Weight	372.41
Flash Point	317.8±31.5 °C
Exact Mass	372.083160
PSA	79.82000
LogP	3.54
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.620
InChIKey	MVGSNCBCUWPVDA-RQZCQDPDSA-N
SMILES	CC1=C(CC(=O)O)c2cc(F)ccc2C1=Cc1ccc(S(C)(=O)=O)cc1

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Articles32

Exisulind: Aptosyn, FGN 1, Prevatac, sulindac sulfone.

Drugs R. D. 5(4) , 220-6, (2004)

Exisulind [Aptosyn trade mark, FGN 1 trade mark, Prevatac trade mark, sulindac sulfone], the sulfone derivative of sulindac, is the lead compound in a series of selective apoptotic antineoplastic drug...

Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth.

Neoplasia 1(2) , 170-6, (1999)

Sulindac sulfide, a metabolite of the nonsteroidal antiinflammatory drug (NSAID) sulindac sulfoxide, is effective at reducing tumor burden in both familial adenomatous polyposis patients and in animal...

Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells.

Cancer Res. 60(23) , 6607-10, (2000)

Both the sulfide and sulfone metabolites of sulindac, a nonsteroidal anti-inflammatory drug, display anticarcinogenic effects in experimental models. Sulindac sulfide inhibits cyclooxygenase (COX) enz...

Synonyms

MFCD01317811

2-[6-fluoro-2-methyl-3-[(4-methylsulfonylphenyl)methylidene]inden-1-yl]acetic acid

Exisulind

1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (1Z)-

Sulindac Sulfone

{(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid

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