CAS 85650-57-3|Setiptiline (maleate)

Introduction：Basic information about CAS 85650-57-3|Setiptiline (maleate), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Setiptiline (maleate) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Setiptiline (maleate)
CAS Number	85650-57-3	Molecular Weight	377.43300
Density	/	Boiling Point	421.7ºC at 760 mmHg
Molecular Formula	C₂₃H₂₃NO₄	Melting Point	/
MSDS	/	Flash Point	185.5ºC

Names

Name	setiptiline maleate
Synonym	More Synonyms

Setiptiline (maleate) BiologicalActivity

Description	Setiptiline is a serotonin receptor antagonist.IC50 value:Target: 5-HT receptorSetiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine. From Wikipedia.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorNatural Products >>AlkaloidResearch Areas >>Neurological Disease
References	[1]. Niho T, et al. [Pharmacological properties of MO-8282, a novel antidepressant]. Nihon Yakurigaku Zasshi. 1986 Oct;88(4):309-20. [2]. Setiptiline [3]. Yamada K, et al. [Behavioral effects of a new antidepressant, setiptiline]. Nihon Yakurigaku Zasshi. 1991 Jan;97(1):31-9. [4]. Kamimura M, et al. The effect of age on plasma level of setiptiline maleate in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Oct;18(6):1015-26. [5]. Kuniyoshi M, et al. Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Mar;18(2):339-46.

Description

Setiptiline is a serotonin receptor antagonist.IC50 value:Target: 5-HT receptorSetiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine. From Wikipedia.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorNatural Products >>AlkaloidResearch Areas >>Neurological Disease

References

[1]. Niho T, et al. [Pharmacological properties of MO-8282, a novel antidepressant]. Nihon Yakurigaku Zasshi. 1986 Oct;88(4):309-20.

[2]. Setiptiline

[3]. Yamada K, et al. [Behavioral effects of a new antidepressant, setiptiline]. Nihon Yakurigaku Zasshi. 1991 Jan;97(1):31-9.

[4]. Kamimura M, et al. The effect of age on plasma level of setiptiline maleate in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Oct;18(6):1015-26.

[5]. Kuniyoshi M, et al. Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Mar;18(2):339-46.

Chemical & Physical Properties

Boiling Point	421.7ºC at 760 mmHg
Molecular Formula	C₂₃H₂₃NO₄
Molecular Weight	377.43300
Flash Point	185.5ºC
Exact Mass	377.16300
PSA	77.84000
LogP	3.48680
InChIKey	AVPIBVPBCWBXIU-BTJKTKAUSA-N
SMILES	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12.O=C(O)C=CC(=O)O
Storage condition	-20°C

Synonyms

MO-8282

MOD-20

Setiptiline (maleate)

Teciptiline maleate

Tecipul

Setiptiline maleate (JAN)

EINECS 288-065-3

Tecipul (TN)

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