Introduction：Basic information about CAS 433967-28-3|VU 0357121, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | VU 0357121 |
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| CAS Number | 433967-28-3 | Molecular Weight | 305.319 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 338.7±42.0 °C at 760 mmHg |
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| Molecular Formula | C17H17F2NO2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 158.7±27.9 °C |
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| Symbol |
GHS09 | Signal Word | Warning |
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Names
| Name | 4-Butoxy-N-(2,4-difluorophenyl)benzamide |
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| Synonym | More Synonyms |
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VU 0357121 BiologicalActivity
| Description | VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.IC50 Value: 33 nM(EC50)Target: mGluR5in vitro: VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. in vivo: |
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| Related Catalog | Research Areas >>Neurological Disease |
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| References | [1]. Hammond, Alexis S.; Rodriguez, Alice L.; Townsend, Steven D. et al. Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chemical Neuroscience (2010), 1(10), 702-716. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 338.7±42.0 °C at 760 mmHg |
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| Molecular Formula | C17H17F2NO2 |
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| Molecular Weight | 305.319 |
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| Flash Point | 158.7±27.9 °C |
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| Exact Mass | 305.122742 |
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| PSA | 38.33000 |
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| LogP | 4.78 |
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| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
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| Index of Refraction | 1.564 |
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| InChIKey | AHCYOTLTLQTPSU-UHFFFAOYSA-N |
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| SMILES | CCCCOc1ccc(C(=O)Nc2ccc(F)cc2F)cc1 |
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| Storage condition | 2-8°C |
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| Water Solubility | DMSO: ≥18mg/mL |
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Safety Information
| Symbol |
GHS09 |
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| Signal Word | Warning |
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| Hazard Statements | H410 |
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| Precautionary Statements | P273-P501 |
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| Hazard Codes | N |
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| Risk Phrases | 50/53 |
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| Safety Phrases | 60-61 |
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| RIDADR | UN 3077 9 / PGIII |
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Synonyms
| Benzamide, 4-butoxy-N-(2,4-difluorophenyl)- |
| 4-Butoxy-N-(2,4-difluorophenyl)benzamide |
| 4-Butoxy-N-(2,4-difluorophenyl)-benzamide |
| VU 0357121 |
| cc-377 |
| VU-0357121 |
| VU0357121 |
