Introduction：Basic information about CAS 623152-17-0|BMS-582949, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BMS-582949 |
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| CAS Number | 623152-17-0 | Molecular Weight | 406.48 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H26N6O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide |
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| Synonym | More Synonyms |
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BMS-582949 BiologicalActivity
| Description | BMS-582949 (compound 7k) is an orally active and highly selective p38α MAP kinase inhibitor, with IC50 values of 13 nM for p38α, and 50 nM for cellular TNFα. BMS-582949 can be used for research on rheumatoid arthritis[1]. |
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| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/Immunology |
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| Target | p38α:13 nM (IC50) |
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| References | [1]. Liu C, et al. Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases. J Med Chem. 2010 Sep 23;53(18):6629-39. |
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Chemical & Physical Properties
| Molecular Formula | C22H26N6O2 |
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| Molecular Weight | 406.48 |
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| Exact Mass | 406.21200 |
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| PSA | 110.63000 |
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| LogP | 3.69320 |
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| InChIKey | GDTQLZHHDRRBEB-UHFFFAOYSA-N |
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| SMILES | CCCNC(=O)c1cn2ncnc(Nc3cc(C(=O)NC4CC4)ccc3C)c2c1C |
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| Storage condition | -20℃ |
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Synonyms
| 38P |
| 3mvl |
| UNII-CR743OME9E |
| BMS-582949 |
| BMS-582949 HCl |
