CAS 1191385-19-9|B-Raf inhibitor 1 (dihydrochloride)
Introduction：Basic information about CAS 1191385-19-9|B-Raf inhibitor 1 (dihydrochloride), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | B-Raf inhibitor 1 (dihydrochloride) | ||
|---|---|---|---|
| CAS Number | 1191385-19-9 | Molecular Weight | 551.85800 |
| Density | / | Boiling Point | / |
| Molecular Formula | C26H21Cl3N8 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine dihydrochloride |
|---|---|
| Synonym | More Synonyms |
B-Raf inhibitor 1 (dihydrochloride) BiologicalActivity
| Description | B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. |
|---|---|
| Related Catalog | Research Areas >>Cancer |
| Target | B-Raf:1 nM (Ki) B-RafV600E:1 nM (Ki) c-Raf:0.3 nM (Ki) |
| In Vitro | B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC50s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers[1]. |
| References | [1]. Wang X, et al. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41. |
Chemical & Physical Properties
| Molecular Formula | C26H21Cl3N8 |
|---|---|
| Molecular Weight | 551.85800 |
| Exact Mass | 550.09500 |
| PSA | 104.30000 |
| LogP | 8.16210 |
| Storage condition | 2-8℃ |
Synonyms
| B-Raf inhibitor 1 dihydrochloride |
| B-Raf inhibitor 1 (dihydrochloride) |
