CAS 179474-80-7|Prucalopride hydrochloride

Introduction：Basic information about CAS 179474-80-7|Prucalopride hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Prucalopride hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Prucalopride hydrochloride
CAS Number	179474-80-7	Molecular Weight	404.33100
Density	/	Boiling Point	/
Molecular Formula	C₁₈H₂₇Cl₂N₃O₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,hydrochloride
Synonym	More Synonyms

Prucalopride hydrochloride BiologicalActivity

Description	Prucalopride hydrochloride is an orally active, selective and specific 5-HT4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride hydrochloride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride hydrochloride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride hydrochloride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3].
Related Catalog	Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor
References	[1]. Chen M, et al. Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway. Hum Exp Toxicol. 2020 Feb;39(2):173-181. [2]. Wang Y, et al. Prucalopride might improve intestinal motility by promoting the regeneration of the enteric nervous system in diabetic rats. Int J Mol Med. 2022 Jul;50(1):87. [3]. Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.

Description

Prucalopride hydrochloride is an orally active, selective and specific 5-HT4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride hydrochloride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride hydrochloride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride hydrochloride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3].

Related Catalog

Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor

References

[1]. Chen M, et al. Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway. Hum Exp Toxicol. 2020 Feb;39(2):173-181.

[2]. Wang Y, et al. Prucalopride might improve intestinal motility by promoting the regeneration of the enteric nervous system in diabetic rats. Int J Mol Med. 2022 Jul;50(1):87.

[3]. Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.

Chemical & Physical Properties

Molecular Formula	C₁₈H₂₇Cl₂N₃O₃
Molecular Weight	404.33100
Exact Mass	403.14300
PSA	80.31000
LogP	3.98370
InChIKey	KKMOQGWTJRGLNN-UHFFFAOYSA-N
SMILES	COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1.Cl

Synonyms

UNII-M8IYX9Z79V

Prucalopride hydrochloride

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