Introduction：Basic information about CAS 1285515-21-0|GSK2578215A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GSK2578215A |
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| CAS Number | 1285515-21-0 | Molecular Weight | 399.417 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 556.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C24H18FN3O2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 290.1±30.1 °C |
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Names
| Name | 5-(2-fluoropyridin-4-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide |
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| Synonym | More Synonyms |
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GSK2578215A BiologicalActivity
| Description | GSK2578215A is a potent and highly selective LRRK2 inhibitor; exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.IC50 value: ~10 nM(wt-LRRK2; LRRK2 G2019S) [1]Target: LRRK2 inhibitorGSK2578215A exhibits exceptionally high selectivity for LRRK2 across the kinome, substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.3–1.0 μM in cells and in mouse spleen and kidney, but not in brain, following intraperitoneal injection of 100 mg/kg [1]. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Autophagy >>LRRK2Signaling Pathways >>Autophagy >>MitophagyResearch Areas >>Neurological Disease |
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| References | [1]. Reith AD, et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5625-9. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 556.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C24H18FN3O2 |
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| Molecular Weight | 399.417 |
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| Flash Point | 290.1±30.1 °C |
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| Exact Mass | 399.138306 |
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| PSA | 67.60000 |
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| LogP | 3.40 |
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| Appearance of Characters | white to beige |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.651 |
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| InChIKey | WCIGMFCFPXZRMQ-UHFFFAOYSA-N |
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| SMILES | O=C(Nc1cccnc1)c1cc(-c2ccnc(F)c2)ccc1OCc1ccccc1 |
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| Storage condition | 2-8°C |
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| Water Solubility | DMSO: soluble15mg/mL, clear |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl- |
| SMANT hydrochloride |
| UNII-Q641JSF42X |
| GSK2578215A |
| 2-(Benzyloxy)-5-(2-fluoro-4-pyridinyl)-N-(3-pyridinyl)benzamide |
