Introduction：Basic information about CAS 183321-86-0|Desmethyl Erlotinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Desmethyl Erlotinib |
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| CAS Number | 183321-86-0 | Molecular Weight | 379.409 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 572.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H21N3O4 | Melting Point | / |
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| MSDS | / | Flash Point | 300.2±30.1 °C |
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Names
| Name | 2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl }oxy)ethanol |
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| Synonym | More Synonyms |
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Desmethyl Erlotinib BiologicalActivity
| Description | Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| In Vivo | Desmethyl Erlotinib exhibits t1/2 of 11.96±2.01 h in a pharmacokinetic study in Wistar rats[1]. |
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| References | [1]. Thappali SR, et al. Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation.Sci Pharm. 2012 Jul-Sep;80(3):633-46. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 572.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H21N3O4 |
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| Molecular Weight | 379.409 |
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| Flash Point | 300.2±30.1 °C |
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| Exact Mass | 379.153198 |
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| PSA | 85.73000 |
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| LogP | 1.75 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.644 |
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| InChIKey | KOQIAZNBAWFSQM-UHFFFAOYSA-N |
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| SMILES | C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCO)cc23)c1 |
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Synonyms
| 2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl}oxy)ethanol |
| Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]- |
| Desmethyl Erlotinib |
