Introduction：Basic information about CAS 948557-43-5|Tie2 kinase inhibitor, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tie2 kinase inhibitor |
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| CAS Number | 948557-43-5 | Molecular Weight | 439.529 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 699.8±55.0 °C at 760 mmHg |
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| Molecular Formula | C26H21N3O2S | Melting Point | / |
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| MSDS | / | Flash Point | 377.0±31.5 °C |
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Names
| Name | 4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine |
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| Synonym | More Synonyms |
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Tie2 kinase inhibitor BiologicalActivity
| Description | Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| Target | IC50: 250 nM (Tie2)[1] |
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| In Vitro | Tie2 kinase inhibitor 1 (compound 5) has an IC50 of 50 μM for p38 and has moderate to excellent cellular activities (cell IC50=232 nM)[1]. Tie2 kinase inhibitor 1 inhibits tunica internal endothelial cell kinase 2 (Tie2)[2]. |
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| In Vivo | Tie2 kinase inhibitor 1 (intraperitoneally; 50 mg/kg; twice a week for 6 weeks) results in statistically significant reductions in tumor volume by day 15. Tie2 kinase inhibitor 1 results in a 61% reduction in tumor volume by day 20, and reduces tumor volume by 45% by 6 weeks[1]. Animal Model: Athymic nude mice (6- to 8-week-old females)[1] Dosage: 50 mg/kg Administration: Intraperitoneally; twice a week for 6 weeks Result: Resulted in statistically significant reductions in tumor volume. |
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| References | [1]. Semones M, et al. Pyridinylimidazole inhibitors of Tie2 kinase. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4756-60. Epub 2007 Jun 27. [2]. Hasenstein JR, et al. Efficacy of Tie2 receptor antagonism in angiosarcoma. Neoplasia. 2012 Feb;14(2):131-40. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 699.8±55.0 °C at 760 mmHg |
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| Molecular Formula | C26H21N3O2S |
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| Molecular Weight | 439.529 |
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| Flash Point | 377.0±31.5 °C |
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| Exact Mass | 439.135437 |
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| PSA | 87.08000 |
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| LogP | 5.31 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.746 |
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| InChIKey | SINQIEAULQKUPD-UHFFFAOYSA-N |
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| SMILES | COc1ccc2cc(-c3nc(-c4ccc(S(C)=O)cc4)[nH]c3-c3ccncc3)ccc2c1 |
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| Storage condition | -20℃ |
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Safety Information
Synonyms
| S1577_Selleck |
| X7496 |
| 4-{4-(6-Methoxy-2-naphthyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine |
| Tie2 kinase inhibitor-Supplied by Selleck Chemicals |
| 4-{4-(6-methoxynaphthalen-2-yl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine |
| Pyridine, 4-[4-(6-methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]- |
| Tie2 kinase inhibitor |
