CAS 321-02-8|Nicotinic acid mononucleotide
| Common Name | Nicotinic acid mononucleotide | ||
|---|---|---|---|
| CAS Number | 321-02-8 | Molecular Weight | 336.21200 |
| Density | / | Boiling Point | / |
| Molecular Formula | C11H14NO9P | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | 3-Carboxy-1-(5-O-phosphono-β-D-ribofuranosyl)pyridinium |
|---|---|
| Synonym | More Synonyms |
Nicotinic acid mononucleotide BiologicalActivity
| Description | Nicotinic acid mononucleotide (NAMN) is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD+. Nicotinate mononucleotide is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. O'Hara JK, et al. Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum. PLoS One. 2014 Apr 18;9(4):e94061. [2]. Khan JA, et al. Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets. 2007 May;11(5):695-705. |
Chemical & Physical Properties
| Molecular Formula | C11H14NO9P |
|---|---|
| Molecular Weight | 336.21200 |
| Exact Mass | 336.04800 |
| PSA | 167.44000 |
| InChIKey | JOUIQRNQJGXQDC-ZYUZMQFOSA-L |
| SMILES | O=C([O-])c1ccc[n+](C2OC(COP(=O)([O-])[O-])C(O)C2O)c1 |
| Storage condition | 20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles29
More Articles| ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis. Mol. Microbiol. 81(4) , 952-67, (2011) In the homoacetogenic bacterium Sporomusa ovata, phenol and p-cresol are converted into α-ribotides, which are incorporated into biologically active cobamides (Cbas) whose lower ligand bases do not fo... | |
| Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica. Biochim. Biophys. Acta 1840(1) , 464-75, (2014) Cobamide diversity arises from the nature of the nucleotide base. Nicotinate mononucleotide (NaMN):base phosphoribosyltransferases (CobT) synthesize α-linked riboside monophosphates from diverse nucle... | |
| Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis. Biochimie 94(2) , 300-9, (2012) Nicotinate phosphoribosyltransferase (NaPRT, EC 2.4.2.11) catalyzes the conversion of nicotinate (Na) to nicotinate mononucleotide, the first reaction of the Preiss-Handler pathway for the biosynthesi... |
Synonyms
| 3-Carboxy-1-methylpyridiniumiodid |
| Pyridinium,3-carboxy-1-methyl-,iodide |
| Trigonelline hydriodide |
| trigonelline hydroiodide |
| nicotinic acid mononucleotide |
| Nicotinsaeure-iodmethylat |
| Nicotinsaeure-mononucleotid |
| nicotinic acid methiodide |
| nicotinate adenine mononucleotide |
| 3-Carboxy-1-methyl-pyridinium,Jodid |
| 3-carboxy-1-methyl-pyridinium,iodide |
